The Hallmarks of Aging — Deep Dive

What a hallmark is, and the three categories.

1. 1
   The Hallmarks Framework

   Criteria, categories, and the 9→12 evolution
   16 min
   ⭐ 190

The root causes of cellular damage.

1. 1
   Genomic Instability & Telomere Attrition

   Damage to the genetic blueprint
   16 min
   ⭐ 190
2. 2
   Epigenetic Alterations & Loss of Proteostasis

   Corrupting how DNA is read and proteins maintained
   16 min
   ⭐ 190

Responses to damage that turn harmful in excess.

1. 1
   Nutrient Sensing & Mitochondrial Dysfunction

   Growth, repair, and the energy crisis
   16 min
   ⭐ 190
2. 2
   Cellular Senescence: Deep Dive

   The SASP and senolytics
   15 min
   ⭐ 185

The consequences, plus the 2023 additions.

1. 1
   Stem Cell Exhaustion & Altered Communication

   Where damage becomes the aging phenotype
   15 min
   ⭐ 185
2. 2
   The Newest Hallmarks

   Autophagy, inflammation, and dysbiosis (2023)
   15 min
   ⭐ 185

The hallmarks as one interconnected web.

1. 1
   The Hallmarks as a Web

   Interconnection, intervention, and geroscience
   16 min
   ⭐ 190