Lactoferrin
Protein
Also known as: Apolactoferrin, Bovine lactoferrin, LF
B
Grade B💊 100-300mg daily🎯 4 primary uses🔗 3 synergies⚠️ Review warnings
Levels upFitness+50 pts
Overview
Iron-binding protein from milk with antimicrobial, antiviral, and immune-modulating properties. Supports gut and systemic immunity.
Primary Uses
AntimicrobialImmune modulationIron regulationGut immunity
Frequently Asked About Lactoferrin
How much Lactoferrin should I take?
The typical effective range is 100-300mg daily. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take Lactoferrin?
Empty stomach or between meals. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take Lactoferrin with food?
Empty stomach may be optimal.
Does Lactoferrin interact with medications?
Yes — known interactions include May affect iron absorption and Generally safe. If you take any prescription medication, talk to your doctor or pharmacist before starting Lactoferrin.
What does Lactoferrin pair well with?
Lactoferrin stacks well with Probiotics, Zinc, and Vitamin C — these combinations either improve absorption or work synergistically toward common goals.
Who should not take Lactoferrin?
Lactoferrin should be avoided or used with caution by people with Milk/dairy allergy (bovine source). Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of Lactoferrin?
Most people tolerate Lactoferrin well. The most commonly reported side effects are Rare, well tolerated and Mild GI upset possible. Side effects are usually dose-dependent — lowering the dose often resolves them.
Dosage
Typical range
100-300mg daily
Timing
Empty stomach or between meals
With food
Empty stomach may be optimal
Duration
Daily for immune support
Special Populations
Those with recurrent infections, gut issues
Research & Studies
Search the literature now
We haven’t curated landmark studies for Lactoferrinyet — one-click into the primary literature here. PubMed (RCTs) is usually the highest-signal starting point.
Mechanism of Action
- • Binds iron, starving pathogens
- • Direct antimicrobial activity
- • Modulates immune cell activity
- • Enhances gut barrier function
Evidence Quality
Evidence Grade B
Promising research, especially for gut and immunity
Safety & Contraindications
Serious Warnings
- • None significant
Contraindications
- • Milk/dairy allergy (bovine source)
Common Side Effects
- • Rare, well tolerated
- • Mild GI upset possible
Pregnancy & Breastfeeding
Consult healthcare provider
Liver & Kidney Notes
Safe
Interactions
💊 Medications
- • May affect iron absorption
- • Generally safe
🧪 Supplements
- • May reduce iron supplement absorption if taken together
🍽️ Food & Alcohol
- • Empty stomach may enhance effect
Stacking & Synergies
Pairs Well With
Avoid Combining With
Take iron separately
Best Goal Synergies
Immune supportGut health
Buying Guide
What to Look For
- • High purity
- • Low iron saturation
- • Third-party tested
Standardization Markers
Lactoferrin contentPurity percentage
Adulteration risk
Low
Practical Notes
- • Take away from iron supplements
- • Supports gut barrier
- • Safe for long-term use
Tags
immuneantimicrobialproteiniron
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Rice Protein
Plant-based protein from brown rice. Hypoallergenic and pairs well with pea protein for complete amino acid profile.
SBI (Serum-Derived Bovine Immunoglobulins)
Concentrated immunoglobulins that bind pathogens and toxins in the gut, supporting barrier function.
Last reviewed: June 2026 by the Formulate Research Team. Sources cited above; methodology and scoring criteria published here.
Cite this page
Formulate Research Team. (2026, June). Lactoferrin — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/lactoferrin-immune
Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.