L-Glutamine
Amino Acid
Also known as: Glutamine, Gln, L-Glutamine (Wound Healing)
B
Grade B💊 5-20 g daily in divided doses🎯 7 primary uses🔗 3 synergies⚠️ Review warnings
Overview
Most abundant amino acid in the body. Critical for gut lining integrity, immune function, and muscle recovery.
Primary Uses
Gut healthMuscle recoveryImmune supportLeaky gutTissue repairGut healingBurns
Dosage
Typical range
5-20 g daily in divided doses
Timing
Between meals or post-workout
With food
Between meals often better
Duration
Safe long-term
Special Populations
Gut issues, athletes, critical illness
Mechanism of Action
- • Primary fuel for intestinal cells
- • Supports gut barrier integrity
- • Immune cell fuel
- • Muscle protein synthesis
Evidence Quality
Evidence Grade B
Important for gut and muscle
Safety & Contraindications
Serious Warnings
- • Caution in cancer (theoretical)
Contraindications
- • Severe liver disease
- • Some cancers (consult oncologist)
Common Side Effects
- • Well tolerated
Pregnancy & Breastfeeding
Consult healthcare provider
Liver & Kidney Notes
Caution severe liver disease
Interactions
💊 Medications
- • Lactulose interaction
🧪 Supplements
- • Works with zinc carnosine for gut
🍽️ Food & Alcohol
- • No interactions
Stacking & Synergies
Pairs Well With
Zinc carnosineProbioticsBCAAs
Avoid Combining With
None typically
Best Goal Synergies
Gut healingMuscle recovery
Buying Guide
What to Look For
- • L-form
- • Pure
Standardization Markers
L-glutamine purity
Adulteration risk
Low
Practical Notes
- • Higher doses for gut healing
- • Primary fuel for gut cells
- • High doses for burns/trauma
- • Important for gut healing
Tags
amino acidgut healthmuscleimmunewoundgut
Frequently Asked About L-Glutamine
How much L-Glutamine should I take?
The typical effective range is 5-20 g daily in divided doses. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take L-Glutamine?
Between meals or post-workout. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take L-Glutamine with food?
Between meals often better.
Does L-Glutamine interact with medications?
Yes — known interactions include Lactulose interaction. If you take any prescription medication, talk to your doctor or pharmacist before starting L-Glutamine.
What does L-Glutamine pair well with?
L-Glutamine stacks well with Zinc carnosine, Probiotics, and BCAAs — these combinations either improve absorption or work synergistically toward common goals.
Who should not take L-Glutamine?
L-Glutamine should be avoided or used with caution by people with Severe liver disease and Some cancers (consult oncologist). Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of L-Glutamine?
Most people tolerate L-Glutamine well. The most commonly reported side effects are Well tolerated. Side effects are usually dose-dependent — lowering the dose often resolves them.
Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.