Naringenin
Antioxidant
Also known as: Grapefruit flavonoid
C
Grade C💊 100-500mg daily🎯 4 primary uses🔗 2 synergies⚠️ Review warnings
Overview
Grapefruit flavonoid with metabolic and liver-protective properties. Supports lipid metabolism and insulin sensitivity.
Primary Uses
Metabolic supportLiver protectionLipid metabolismInsulin sensitivity
Dosage
Typical range
100-500mg daily
Timing
With meals
With food
Yes
Duration
Long-term appears safe
Special Populations
Metabolic support, liver health
Mechanism of Action
- • Activates AMPK
- • Supports lipid metabolism
- • Hepatoprotective
- • Improves insulin sensitivity
Evidence Quality
Evidence Grade C
Promising metabolic research, grapefruit drug interactions apply
Safety & Contraindications
Serious Warnings
- • Grapefruit-drug interactions apply
- • Inhibits CYP3A4
Contraindications
- • Many medications (CYP3A4 substrates)
Common Side Effects
- • Well tolerated
Pregnancy & Breastfeeding
Avoid concentrated forms
Liver & Kidney Notes
Hepatoprotective but check drug interactions
Interactions
💊 Medications
- • MANY - same as grapefruit juice
- • Statins, calcium channel blockers, etc.
🧪 Supplements
- • Works with other metabolic support
🍽️ Food & Alcohol
- • Grapefruit is source
Stacking & Synergies
Pairs Well With
BerberineOther metabolic polyphenols
Avoid Combining With
CYP3A4-metabolized drugs
Best Goal Synergies
Metabolic healthLiver support
Buying Guide
What to Look For
- • Purity
- • Understand drug interactions
Standardization Markers
Naringenin content
Adulteration risk
Low
Practical Notes
- • Same drug interactions as grapefruit
- • Check all medications before using
- • Metabolic benefits promising
Tags
polyphenolflavonoidmetabolicliver
Frequently Asked About Naringenin
How much Naringenin should I take?
The typical effective range is 100-500mg daily. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take Naringenin?
With meals. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take Naringenin with food?
Yes.
Does Naringenin interact with medications?
Yes — known interactions include MANY - same as grapefruit juice and Statins, calcium channel blockers, etc.. If you take any prescription medication, talk to your doctor or pharmacist before starting Naringenin.
What does Naringenin pair well with?
Naringenin stacks well with Berberine and Other metabolic polyphenols — these combinations either improve absorption or work synergistically toward common goals.
Who should not take Naringenin?
Naringenin should be avoided or used with caution by people with Many medications (CYP3A4 substrates). Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of Naringenin?
Most people tolerate Naringenin well. The most commonly reported side effects are Well tolerated. Side effects are usually dose-dependent — lowering the dose often resolves them.
Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.