PEA (Palmitoylethanolamide)
Anti-inflammatory
Also known as: Levagen, PEA, PEA (lipid), Palmidrol, Palmitoylethanolamide
B
Grade B💊 300-600 mg daily🎯 4 primary uses🔗 2 synergies⚠️ Review warnings
Levels upHeart & Longevity+50 pts
Overview
Endogenous fatty acid amide with anti-inflammatory and neuroprotective effects. Different from phenylethylamine.
Primary Uses
PainNeuroprotectionInflammationImmune modulation
Frequently Asked About PEA (Palmitoylethanolamide)
How much PEA (Palmitoylethanolamide) should I take?
The typical effective range is 300-600 mg daily. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take PEA (Palmitoylethanolamide)?
Divided doses. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take PEA (Palmitoylethanolamide) with food?
Optional.
Does PEA (Palmitoylethanolamide) interact with medications?
Yes — known interactions include None significant. If you take any prescription medication, talk to your doctor or pharmacist before starting PEA (Palmitoylethanolamide).
What does PEA (Palmitoylethanolamide) pair well with?
PEA (Palmitoylethanolamide) stacks well with Omega-3s and Curcumin — these combinations either improve absorption or work synergistically toward common goals.
Who should not take PEA (Palmitoylethanolamide)?
PEA (Palmitoylethanolamide) should be avoided or used with caution by people with None known. Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of PEA (Palmitoylethanolamide)?
Most people tolerate PEA (Palmitoylethanolamide) well. The most commonly reported side effects are Minimal. Side effects are usually dose-dependent — lowering the dose often resolves them.
Dosage
Typical range
300-600 mg daily
Timing
Divided doses
With food
Optional
Duration
Safe long-term
Special Populations
Chronic pain, neuropathy, inflammation
Research & Studies
Search the literature now
We haven’t curated landmark studies for PEA (Palmitoylethanolamide)yet — one-click into the primary literature here. PubMed (RCTs) is usually the highest-signal starting point.
Search PEA (Palmitoylethanolamide) research
Mechanism of Action
- • PPARα activation
- • Mast cell modulation
- • Endocannabinoid support
Evidence Quality
Evidence Grade B
Endogenous anti-inflammatory lipid
Safety & Contraindications
Serious Warnings
- • None established
Contraindications
- • None known
Common Side Effects
- • Minimal
Pregnancy & Breastfeeding
Limited data
Liver & Kidney Notes
Safe
Interactions
💊 Medications
- • None significant
🧪 Supplements
- • Works with omega-3s
🍽️ Food & Alcohol
- • No interactions
Stacking & Synergies
Buying Guide
What to Look For
- • Micronized/ultra-micronized
Standardization Markers
Micronized formPEA content
Adulteration risk
Low
Practical Notes
- • Different from phenylethylamine (mood PEA)
- • Micronized form absorbs better
Tags
anti-inflammatorypainneuroprotectionendocannabinoid
Top Products with PEA (Palmitoylethanolamide)
Highest-scored catalog products containing PEA (Palmitoylethanolamide), ranked by our scoring engine.
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Last reviewed: September 2026 by the Formulate Research Team. Sources cited above; methodology and scoring criteria published here.
Cite this page
Formulate Research Team. (2026, September). PEA (Palmitoylethanolamide) — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/palmitoylethanolamide
Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.