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PEA (Palmitoylethanolamide)

Anti-inflammatory

Also known as: Levagen, PEA, PEA (lipid), Palmidrol, Palmitoylethanolamide

B
Grade B
πŸ’Š 300-600 mg daily🎯 4 primary usesπŸ”— 2 synergies⚠️ Review warnings

Overview

Endogenous fatty acid amide with anti-inflammatory and neuroprotective effects. Different from phenylethylamine.

Primary Uses
PainNeuroprotectionInflammationImmune modulation

Dosage

Typical range
300-600 mg daily
Timing
Divided doses
With food
Optional
Duration

Safe long-term

Special Populations

Chronic pain, neuropathy, inflammation

Mechanism of Action

  • β€’ PPARΞ± activation
  • β€’ Mast cell modulation
  • β€’ Endocannabinoid support

Evidence Quality

Evidence Grade B

Endogenous anti-inflammatory lipid

Safety & Contraindications

Serious Warnings
  • β€’ None established
Contraindications
  • β€’ None known
Common Side Effects
  • β€’ Minimal
Pregnancy & Breastfeeding

Limited data

Liver & Kidney Notes

Safe

Interactions

πŸ’Š Medications
  • β€’ None significant
πŸ§ͺ Supplements
  • β€’ Works with omega-3s
🍽️ Food & Alcohol
  • β€’ No interactions

Stacking & Synergies

Pairs Well With
Omega-3sCurcumin
Avoid Combining With
None
Best Goal Synergies
PainInflammation

Buying Guide

What to Look For
  • β€’ Micronized/ultra-micronized
Standardization Markers
Micronized formPEA content
Adulteration risk
Low
Practical Notes
  • β€’ Different from phenylethylamine (mood PEA)
  • β€’ Micronized form absorbs better
Tags
anti-inflammatorypainneuroprotectionendocannabinoid

Frequently Asked About PEA (Palmitoylethanolamide)

How much PEA (Palmitoylethanolamide) should I take?
The typical effective range is 300-600 mg daily. Individual needs vary based on age, body weight, diet, and goals β€” start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take PEA (Palmitoylethanolamide)?
Divided doses. Consistency matters more than perfect timing β€” pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take PEA (Palmitoylethanolamide) with food?
Optional.
Does PEA (Palmitoylethanolamide) interact with medications?
Yes β€” known interactions include None significant. If you take any prescription medication, talk to your doctor or pharmacist before starting PEA (Palmitoylethanolamide).
What does PEA (Palmitoylethanolamide) pair well with?
PEA (Palmitoylethanolamide) stacks well with Omega-3s and Curcumin β€” these combinations either improve absorption or work synergistically toward common goals.
Who should not take PEA (Palmitoylethanolamide)?
PEA (Palmitoylethanolamide) should be avoided or used with caution by people with None known. Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of PEA (Palmitoylethanolamide)?
Most people tolerate PEA (Palmitoylethanolamide) well. The most commonly reported side effects are Minimal. Side effects are usually dose-dependent β€” lowering the dose often resolves them.

Educational content based on published research and our scoring methodology. Not medical advice β€” consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.