Phosphatidic Acid
Performance
Also known as: Mediator, Mediator PA, PA, Phosphatidic Acid (PA), Phosphatidic acid
C
Grade C💊 750mg🎯 3 primary uses🔗 2 synergies⚠️ Review warnings
Overview
Signaling lipid that activates mTOR. May enhance muscle protein synthesis response.
Primary Uses
Muscle buildingmTOR activationStrength gains
Dosage
Typical range
750mg
Timing
Pre-workout or with meals
With food
Yes, with fat
Duration
8+ weeks for effects
Special Populations
Muscle building focus
Mechanism of Action
- • Activates mTOR pathway
- • Enhances response to training
- • Cell signaling lipid
Evidence Quality
Evidence Grade C
Emerging research for muscle building
Safety & Contraindications
Serious Warnings
- • None known
Contraindications
- • Soy allergy (check source)
Common Side Effects
- • GI upset
Pregnancy & Breastfeeding
Insufficient data
Liver & Kidney Notes
No concerns
Interactions
💊 Medications
- • None known
🧪 Supplements
- • Protein
- • Creatine
🍽️ Food & Alcohol
- • With fat-containing meal
Stacking & Synergies
Pairs Well With
ProteinCreatine
Avoid Combining With
Nothing
Best Goal Synergies
Muscle hypertrophy
Buying Guide
What to Look For
- • Mediator or quality brand
Standardization Markers
Mediator brandSunflower-derived
Adulteration risk
Moderate
Practical Notes
- • Emerging research
- • Take with resistance training
Tags
performancemusclemTORsignaling
Frequently Asked About Phosphatidic Acid
How much Phosphatidic Acid should I take?
The typical effective range is 750mg. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take Phosphatidic Acid?
Pre-workout or with meals. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take Phosphatidic Acid with food?
Yes, with fat.
Does Phosphatidic Acid interact with medications?
Yes — known interactions include None known. If you take any prescription medication, talk to your doctor or pharmacist before starting Phosphatidic Acid.
What does Phosphatidic Acid pair well with?
Phosphatidic Acid stacks well with Protein and Creatine — these combinations either improve absorption or work synergistically toward common goals.
Who should not take Phosphatidic Acid?
Phosphatidic Acid should be avoided or used with caution by people with Soy allergy (check source). Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of Phosphatidic Acid?
Most people tolerate Phosphatidic Acid well. The most commonly reported side effects are GI upset. Side effects are usually dose-dependent — lowering the dose often resolves them.
Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.