Polygala tenuifolia

Nootropic

Also known as: Yuan Zhi, Chinese senega, Polygala tenuifolia 20:1 Extract, Thin-leaf Milkwort, Polygalae radix

Grade B

💊 100-300 mg extract daily🎯 9 primary uses🔗 2 synergies⚠️ Review warnings

Overview

A traditional Chinese herb used for centuries to support memory, cognitive clarity, and emotional balance; the 20:1 extract represents a concentrated form standardized to preserve bioactive constituents. Modern research suggests potential nootropic and anxiolytic properties, though human clinical evidence remains limited.

Primary Uses

MemoryMoodBDNF supportAnti-anxietyMemory and learning enhancementCognitive clarity and focusMood and emotional stabilitySleep qualityStress and anxiety reduction

Dosage

Typical range

100-300 mg extract daily

Timing

Any time

With food

Optional

Duration

Weeks for effects

Special Populations

Memory, mild anxiety

Mechanism of Action

• May increase BDNF
• Anti-inflammatory in brain
• Traditional memory tonic

Evidence Quality

Evidence Grade B

Traditional cognitive herb

Safety & Contraindications

Serious Warnings

• None established

Contraindications

• None known

Common Side Effects

• GI upset

Pregnancy & Breastfeeding

Avoid

Liver & Kidney Notes

Safe

Interactions

💊 Medications

• Unknown

🧪 Supplements

• Works with other nootropics

🍽️ Food & Alcohol

• No interactions

Stacking & Synergies

Pairs Well With

Lion's maneBacopa

Avoid Combining With

None known

Best Goal Synergies

MemoryMood

Buying Guide

What to Look For

• Standardized extract

Standardization Markers

Tenuifolin content

Adulteration risk

Moderate

Practical Notes

• Traditional Chinese memory herb
• Limited but promising research

Frequently Asked About Polygala tenuifolia

How much Polygala tenuifolia should I take?

The typical effective range is 100-300 mg extract daily. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.

When is the best time to take Polygala tenuifolia?

Any time. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.

Should I take Polygala tenuifolia with food?

Optional.

Does Polygala tenuifolia interact with medications?

Yes — known interactions include Unknown. If you take any prescription medication, talk to your doctor or pharmacist before starting Polygala tenuifolia.

What does Polygala tenuifolia pair well with?

Polygala tenuifolia stacks well with Lion's mane and Bacopa — these combinations either improve absorption or work synergistically toward common goals.

Who should not take Polygala tenuifolia?

Polygala tenuifolia should be avoided or used with caution by people with None known. Pregnant or breastfeeding women should consult a healthcare provider before use.

What are the side effects of Polygala tenuifolia?

Most people tolerate Polygala tenuifolia well. The most commonly reported side effects are GI upset. Side effects are usually dose-dependent — lowering the dose often resolves them.

Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.