TMG (Trimethylglycine/Betaine)
Methylation
Also known as: Betaine anhydrous, Trimethylglycine, Betaine HCl is different
A
Grade A💊 500-3000mg daily🎯 4 primary uses🔗 4 synergies⚠️ Review warnings
Overview
Methyl donor supporting homocysteine metabolism and methylation. Important cofactor when taking NAD+ precursors that consume methyl groups.
Primary Uses
Methylation supportHomocysteine metabolismNAD+ precursor supportLiver health
Dosage
Typical range
500-3000mg daily
Timing
With NAD+ precursors or meals
With food
Optional
Duration
Safe long-term
Special Populations
NAD+ precursor users, MTHFR variants, high homocysteine
Mechanism of Action
- • Donates methyl groups
- • Supports homocysteine remethylation
- • Osmolyte function
- • Liver protective
Evidence Quality
Evidence Grade A
Well-established for homocysteine and methylation support
Safety & Contraindications
Serious Warnings
- • May raise LDL in some
Contraindications
- • None significant
Common Side Effects
- • GI upset
- • Fishy odor at high doses
Pregnancy & Breastfeeding
Consult healthcare provider
Liver & Kidney Notes
Hepatoprotective
Interactions
💊 Medications
- • None significant
🧪 Supplements
- • Essential with NMN/NR
- • Works with B vitamins
🍽️ Food & Alcohol
- • Beets are natural source
Stacking & Synergies
Pairs Well With
NMNNRB vitaminsFolate
Avoid Combining With
None
Best Goal Synergies
MethylationNAD+ support
Buying Guide
What to Look For
- • Anhydrous form
- • Purity
Standardization Markers
TMG content
Adulteration risk
Low
Practical Notes
- • Essential when taking NMN/NR
- • Not same as Betaine HCl (digestive)
- • Beets are food source
Tags
methylationhomocysteinelivernad+
Frequently Asked About TMG (Trimethylglycine/Betaine)
How much TMG (Trimethylglycine/Betaine) should I take?
The typical effective range is 500-3000mg daily. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take TMG (Trimethylglycine/Betaine)?
With NAD+ precursors or meals. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take TMG (Trimethylglycine/Betaine) with food?
Optional.
Does TMG (Trimethylglycine/Betaine) interact with medications?
Yes — known interactions include None significant. If you take any prescription medication, talk to your doctor or pharmacist before starting TMG (Trimethylglycine/Betaine).
What does TMG (Trimethylglycine/Betaine) pair well with?
TMG (Trimethylglycine/Betaine) stacks well with NMN, NR, and B vitamins — these combinations either improve absorption or work synergistically toward common goals.
Who should not take TMG (Trimethylglycine/Betaine)?
TMG (Trimethylglycine/Betaine) should be avoided or used with caution by people with None significant. Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of TMG (Trimethylglycine/Betaine)?
Most people tolerate TMG (Trimethylglycine/Betaine) well. The most commonly reported side effects are GI upset and Fishy odor at high doses. Side effects are usually dose-dependent — lowering the dose often resolves them.
Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.