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Catalog/Methyl-Guard Plus®
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Methyl-Guard Plus®

🅱️B Vitamins
💊Capsule
❤️Heart🧬Methylation🌙SleepEnergy
🏭GMP📊Clinical Evidence💪Optimal Doses

Support cellular energy production, heart health, brain function, and mood with nutrients that optimize methylation* Methyl-Guard Plus provides superior methyl donors – trimethylglycine, 5-MTHF, and methylcobalamin – combined with bioactive vitamins B2 and B6 in a powerhouse formula for whole-body methylation support.*

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Description

Methyl-Guard Plus® Details Various conditions and stressors can have an adverse impact on the body's methylation cycle. Nutrient deficiencies, environmental exposures, and other aspects of a modern lifestyle can cause inefficient methylation. In addition, approximately 60 percent of U.S. adults have a genetic variation that makes it difficult for their methylation cycle to function optimally. Thorne's Methyl-Guard Plus features betaine (trimethylglycine), methylated vitamin B12 (methylcobalamin) and folate (5-MTHF), as well as the active forms of vitamins B2 and B6, for providing efficient nutritional support for the body's methylation challenges.* Benefits of Thorne's Methyl-Guard Plus • Nutritional support for individuals who have MTHFR gene variations* • Enhanced cellular energy production fights occasional fatigue* • Helps maintain a healthy homocysteine level in the blood, which supports cardiovascular, cognitive, and bone health* • Promotes fat metabolism and lean body composition* • Supports neurotransmitter production – natural chemicals that play an important role in nervous system functions, like attention, focus, mood, and sleep* • Promotes liver detoxification of many substances, including hormones like estrogen* Why is methylation important? Methylation is a simple reaction where a small molecule known as a "methyl group" is transferred from one substance to another. Methylation significantly impacts many biochemical reactions in the body and plays a beneficial role in: • Cardiovascular health • Cellular energy production • Fat metabolism • Neurological function • DNA production • Liver detoxification processes • Eye health • Histamine balance Who can benefit from Thorne's Methyl-Guard Plus • Individuals with variations to MTHFR and other genes that adversely affect methylation* • Aging individuals wanting to support their cardiovascular, cognitive, and metabolic health* • Women seeking support for estrogen metabolism and bone health* • Individuals wanting nutritional support for fat metabolism and maintenance of a healthy body composition* • Anyone with limited consumption of methylation-supportive foods like green leafy vegetables, legumes, and cruciferous vegetables Features of Thorne's Methyl-Guard Plus • Betaine, also known as trimethylglycine, is a superior methyl donor • The methylated forms of vitamin B12 (methylcobalamin) and folate (5-MTHF) benefit individuals with certain gene mutations* • Active forms of vitamins B2 and B6 – key cofactors in methylation processes • B vitamins in their active, tissue-ready forms means your body gets the greatest benefit with the least additional work* • Robust methylation support in fewer capsules per day than Thorne's original Methyl-Guard®

Recommended Use

Take 1-3 capsules daily or as recommended by your health-care practitioner.

Warnings

ALLERGY WARNING: This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients. PREGNANCY: If pregnant, consult your health-care practitioner before using this product. INTERACTIONS: 5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrently with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity. however, 5-MTHF has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.

Active Ingredients

Betaine Anhydrous
Trimethylglycine
1.8g
55% TR
OPTIMALCLINICAL
Vitamin B12
Methylcobalamin
3mg
125000% DV
OPTIMALCLINICAL
Riboflavin
Riboflavin 5'-Phosphate Sodium
90mg
6923% DV
OPTIMALHIGH
Vitamin B6
Pyridoxal 5'-Phosphate
45mg
2647% DV
OPTIMALGOOD
Folate
3 mg as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt
5mg
1250% DV
OPTIMALGOOD

Other Ingredients

Calcium Citrate, Calcium Laurate, Hypromellose (derived from cellulose) capsule

Product Info

Serving Size
3 Capsules
Servings
30
Price
$62.00
Per Serving
$2.07
Form
capsule

Where to Buy

Links may contain affiliate partnerships. See our disclosure for details.

Certifications

Gluten FreeSoy FreeDairy FreeNatural FlavorsNatural ColorsMade in USAThorne VerifiedGMP Certified

Score Breakdown

Evidence Quality
30%96
3 Grade A, 1 Grade B ingredients
Evidence grades: A(3), B(1)
Dose Adequacy
25%95
5 ingredients at optimal doses
Reference coverage: 100%
Form/Bioavailability
15%85
2 clinical: Betaine Anhydrous, Vitamin B12
1 high: Riboflavin
2 good: Vitamin B6, Folate
Good form quality - mostly bioavailable forms
Transparency
15%100
Label transparency: full
Safety/Redundancy
10%100
Focused formula (5 ingredients)
Manufacturing Quality
5%92
NSF Certified for Sport (premium)
Overall Score95/100

Systems supported

body systems this product feeds

Pathways supported

biochemical reactions enabled by this product

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