Adrafinil
Nootropic
Also known as: Olmifon
C
Grade C💊 300-600 mg daily🎯 3 primary uses🔗 1 synergy⚠️ Review warnings
Levels upCognition+50 pts
Overview
Prodrug converting to modafinil in the liver. Unscheduled in many countries but requires liver monitoring.
Primary Uses
WakefulnessFocusAlertness
Frequently Asked About Adrafinil
How much Adrafinil should I take?
The typical effective range is 300-600 mg daily. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take Adrafinil?
Morning. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take Adrafinil with food?
Optional.
Does Adrafinil interact with medications?
Yes — known interactions include Same as modafinil. If you take any prescription medication, talk to your doctor or pharmacist before starting Adrafinil.
What does Adrafinil pair well with?
Adrafinil stacks well with Nothing required — these combinations either improve absorption or work synergistically toward common goals.
Who should not take Adrafinil?
Adrafinil should be avoided or used with caution by people with Liver disease. Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of Adrafinil?
Most people tolerate Adrafinil well. The most commonly reported side effects are Same as modafinil and Liver enzyme elevation. Side effects are usually dose-dependent — lowering the dose often resolves them.
Dosage
Typical range
300-600 mg daily
Timing
Morning
With food
Optional
Duration
Not for daily long-term use
Special Populations
Occasional use only
Research & Studies
Search the literature now
We haven’t curated landmark studies for Adrafinilyet — one-click into the primary literature here. PubMed (RCTs) is usually the highest-signal starting point.
Mechanism of Action
- • Converts to modafinil in liver
- • Similar mechanism once converted
Evidence Quality
Evidence Grade C
Prodrug - liver concerns with long-term use
Safety & Contraindications
Serious Warnings
- • Liver strain with chronic use
Contraindications
- • Liver disease
Common Side Effects
- • Same as modafinil
- • Liver enzyme elevation
Pregnancy & Breastfeeding
Avoid
Liver & Kidney Notes
Monitor liver enzymes
Interactions
💊 Medications
- • Same as modafinil
🧪 Supplements
- • Liver support may help
🍽️ Food & Alcohol
- • Alcohol strains liver more
Stacking & Synergies
Pairs Well With
Nothing required
Avoid Combining With
Hepatotoxic substances
Best Goal Synergies
Occasional alertness
Buying Guide
What to Look For
- • Lab-tested
Standardization Markers
Purity
Adulteration risk
Moderate
Practical Notes
- • Not for chronic use - liver strain
- • Consider modafinil with prescription instead
Tags
nootropicprodrugwakefulness
More in Nootropic
Other ingredients in the Nootropic category.
Acetyl-L-Carnitine (ALCAR)
Acetyl L-Carnitine is a form of carnitine that crosses the blood-brain barrier and supports mitochondrial energy production and acetylcholine synthesis. It has shown modest benefits for cognitive function and energy metabolism in some studies, with stronger evidence in elderly populations and carnitine-deficient states.
Alpha-GPC
Highly bioavailable choline source crossing the blood-brain barrier. Supports acetylcholine and growth hormone.
American Ginseng
American ginseng is a traditional herbal adaptogen used to support energy, immune function, and stress resilience. Moderate evidence supports benefits for fatigue and immune support, though effects are generally modest and more research is needed.
Aniracetam
Fat-soluble racetam with anxiolytic properties. Enhances creativity, verbal fluency, and reduces anxiety.
Ashwagandha
Ashwagandha is a traditional Ayurvedic herb standardized for withanolides, with evidence supporting modest benefits for stress reduction, anxiety, and cortisol modulation. Multiple clinical trials demonstrate efficacy for stress-related symptoms, though effect sizes are generally moderate.
Bacopa monnieri
Bacopa monnieri is a traditional Ayurvedic herb standardized for bacosides, compounds with demonstrated effects on memory consolidation and cognitive processing speed in multiple clinical trials. Evidence suggests it may support learning and mental clarity, particularly with consistent use over weeks to months.
Last reviewed: June 2026 by the Formulate Research Team. Sources cited above; methodology and scoring criteria published here.
Cite this page
Formulate Research Team. (2026, June). Adrafinil — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/adrafinil
Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.