Also known as: Folate, L-methylfolate, 5-MTHF, Metafolin
Active form of folate for those with MTHFR variants. Critical for methylation and mood.
Daily essential
MTHFR, depression, pregnancy
We haven’t curated landmark studies for Methylfolateyet — one-click into the primary literature here. PubMed (RCTs) is usually the highest-signal starting point.
Essential nutrient with clear mood connection
Essential for pregnancy
No concerns
In-depth guides covering Methylfolate — protocols, comparisons, and use cases.
Other ingredients in the Vitamin category.
Formulate Research Team. (2026, September). Methylfolate — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/folate-methylfolate
Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.