Pregnenolone
Hormone Support
Also known as: Mother hormone, PREG, Steroid precursor
C
Grade C💊 5-50mg daily🎯 7 primary uses🔗 1 synergy⚠️ Review warnings
Overview
Precursor hormone supporting overall steroid hormone production including cortisol.
Primary Uses
Hormone supportCognitive functionMoodMemoryHPA axis supportHormone balanceCognition
Dosage
Typical range
5-50mg daily
Timing
Morning
With food
With fat
Duration
Cycle recommended
Special Populations
Age-related decline
Mechanism of Action
- • Precursor to all steroid hormones
- • Neurosteroid with brain effects
- • Modulates GABA and NMDA
Evidence Quality
Evidence Grade C
Limited clinical evidence
Safety & Contraindications
Serious Warnings
- • Unpredictable hormone conversion
Contraindications
- • Hormone-sensitive cancers
Common Side Effects
- • Irritability
- • Acne
- • Hair changes
Pregnancy & Breastfeeding
Avoid
Liver & Kidney Notes
Hormone metabolism
Interactions
💊 Medications
- • Hormone therapies
🧪 Supplements
- • DHEA (similar pathway)
🍽️ Food & Alcohol
- • Take with fat
Stacking & Synergies
Pairs Well With
None specifically
Avoid Combining With
Other hormones without testing
Best Goal Synergies
Hormone optimization
Buying Guide
What to Look For
- • Third-party tested
Standardization Markers
Micronized form
Adulteration risk
Moderate
Practical Notes
- • Test hormone levels before/during
- • Start very low
- • Test hormones before/during
- • Low dose approach
Tags
hormoneprecursorcognitionneurosteroidHPA
Frequently Asked About Pregnenolone
How much Pregnenolone should I take?
The typical effective range is 5-50mg daily. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take Pregnenolone?
Morning. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take Pregnenolone with food?
With fat.
Does Pregnenolone interact with medications?
Yes — known interactions include Hormone therapies. If you take any prescription medication, talk to your doctor or pharmacist before starting Pregnenolone.
What does Pregnenolone pair well with?
Pregnenolone stacks well with None specifically — these combinations either improve absorption or work synergistically toward common goals.
Who should not take Pregnenolone?
Pregnenolone should be avoided or used with caution by people with Hormone-sensitive cancers. Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of Pregnenolone?
Most people tolerate Pregnenolone well. The most commonly reported side effects are Irritability, Acne, and Hair changes. Side effects are usually dose-dependent — lowering the dose often resolves them.
Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.