Pterostilbene
Antioxidant
Also known as: Dimethyl resveratrol, Dimethylated resveratrol, Trans-pterostilbene
B
Grade B๐ 50-150 mg daily๐ฏ 4 primary uses๐ 2 synergiesโ ๏ธ Review warnings
Levels upVitality+50 pts
Overview
Methylated resveratrol with 4x better bioavailability. Similar longevity pathway activation.
Primary Uses
LongevityCognitive functionCardiovascular healthBlood sugar
Frequently Asked About Pterostilbene
How much Pterostilbene should I take?
The typical effective range is 100-250 mg/day. Individual needs vary based on age, body weight, diet, and goals โ start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take Pterostilbene?
With food. Consistency matters more than perfect timing โ pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take Pterostilbene with food?
Yes.
Does Pterostilbene interact with medications?
Yes โ known interactions include Blood thinners and CYP450. If you take any prescription medication, talk to your doctor or pharmacist before starting Pterostilbene.
What does Pterostilbene pair well with?
Pterostilbene stacks well with Resveratrol and NMN/NR โ these combinations either improve absorption or work synergistically toward common goals.
Who should not take Pterostilbene?
Pterostilbene should be avoided or used with caution by people with High LDL (monitor). Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of Pterostilbene?
Most people tolerate Pterostilbene well. The most commonly reported side effects are May raise LDL slightly. Side effects are usually dose-dependent โ lowering the dose often resolves them.
Dosage
Typical range
50-150 mg daily
Timing
With food
With food
Yes
Dose Tiers
Moderate
50-150 mg/day
Optimal
100-250 mg/day
Upper Limit
LDL elevation at high doses
Duration
Safe long-term
Special Populations
Longevity, cognitive focus
Research & Studies
Search the literature now
We havenโt curated landmark studies for Pterostilbeneyet โ one-click into the primary literature here. PubMedย (RCTs) is usually the highest-signal starting point.
Mechanism of Action
- โข 4x better bioavailability than resveratrol
- โข Activates SIRT1
- โข Longer half-life
Evidence Quality
Evidence Grade B
Better absorbed resveratrol analog
Safety & Contraindications
Serious Warnings
- โข LDL increase in some
Contraindications
- โข High LDL (monitor)
Common Side Effects
- โข May raise LDL slightly
Pregnancy & Breastfeeding
Avoid
Liver & Kidney Notes
Safe
Interactions
๐ Medications
- โข Blood thinners
- โข CYP450
๐งช Supplements
- โข Works with resveratrol
๐ฝ๏ธ Food & Alcohol
- โข Blueberries are source
Stacking & Synergies
Pairs Well With
Avoid Combining With
Monitor if high LDL
Best Goal Synergies
LongevityCognitive
Buying Guide
What to Look For
- โข Purity
Standardization Markers
Pterostilbene content
Adulteration risk
Low
Practical Notes
- โข Better absorbed than resveratrol
- โข Monitor cholesterol
Tags
antioxidantlongevitycognitivesirtuin
Top Products with Pterostilbene
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Last reviewed: June 2026 by the Formulate Research Team. Sources cited above; methodology and scoring criteria published here.
Cite this page
Formulate Research Team. (2026, June). Pterostilbene โ Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/pterostilbene
Educational content based on published research and our scoring methodology. Not medical advice โ consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.