Reishi
Adaptogen
Also known as: Lingzhi, Ganoderma lucidum, Reishi (Ganoderma lucidum), Spirit mushroom
B
Grade B💊 1000-3000mg or 300-500mg extract🎯 5 primary uses🔗 2 synergies⚠️ Review warnings
Levels upStress & Resilience+50 pts
Overview
The 'mushroom of immortality' - adaptogenic fungus that modulates immune function, reduces stress, and supports longevity.
Primary Uses
Immune modulationSleep qualityStress adaptationLongevitySleep support
Frequently Asked About Reishi
How much Reishi should I take?
The typical effective range is 1,500-3,000 mg/day. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take Reishi?
Evening (calming) or morning. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take Reishi with food?
Either.
Does Reishi interact with medications?
Yes — known interactions include Blood thinners, Immunosuppressants, and BP meds. If you take any prescription medication, talk to your doctor or pharmacist before starting Reishi.
What does Reishi pair well with?
Reishi stacks well with Lion's mane and Chaga — these combinations either improve absorption or work synergistically toward common goals.
Who should not take Reishi?
Reishi should be avoided or used with caution by people with Bleeding disorders and Before surgery. Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of Reishi?
Most people tolerate Reishi well. The most commonly reported side effects are GI upset, Dizziness, and Dry mouth. Side effects are usually dose-dependent — lowering the dose often resolves them.
Dosage
Typical range
1000-3000mg or 300-500mg extract
Timing
Evening (calming) or morning
With food
Either
Dose Tiers
Moderate
1,000-1,500 mg/day extract
Optimal
1,500-3,000 mg/day
Upper Limit
Mild stomach upset at high doses
Duration
Safe long-term
Special Populations
Immune, sleep, stress
Research & Studies
Search the literature now
We haven’t curated landmark studies for Reishiyet — one-click into the primary literature here. PubMed (RCTs) is usually the highest-signal starting point.
Mechanism of Action
- • Beta-glucans for immune modulation
- • Triterpenes for calming
- • Adaptogenic
Evidence Quality
Evidence Grade B
Good immune and calming evidence
Safety & Contraindications
Serious Warnings
- • May affect blood clotting
Contraindications
- • Bleeding disorders
- • Before surgery
Common Side Effects
- • GI upset
- • Dizziness
- • Dry mouth
Pregnancy & Breastfeeding
Avoid
Liver & Kidney Notes
Rare liver issues
Interactions
💊 Medications
- • Blood thinners
- • Immunosuppressants
- • BP meds
🧪 Supplements
- • Other mushrooms
🍽️ Food & Alcohol
- • No interactions
Stacking & Synergies
Pairs Well With
Avoid Combining With
Blood thinners without monitoring
Best Goal Synergies
Immune + calm
Buying Guide
What to Look For
- • Dual extract
- • Fruiting body
Standardization Markers
Beta-glucans 15%+Triterpenes
Adulteration risk
Moderate
Practical Notes
- • Evening dosing for sleep
- • Bitter taste normal
- • Evening use for calming
- • Fruiting body preferred
- • Part of traditional longevity practices
Tags
adaptogenmushroomimmunecalminglongevity
Related Guides
In-depth guides covering Reishi — protocols, comparisons, and use cases.
More in Adaptogen
Other ingredients in the Adaptogen category.
Cordyceps
Energy and performance mushroom that also supports immune function, respiratory health, and adaptogenic resilience.
Eleuthero (Siberian Ginseng)
Classic adaptogen for physical and mental stress, supporting adrenal resilience.
Ginseng
A well-researched adaptogenic herb used for centuries in traditional medicine, shown to support energy, cognitive function, immune health, and stress resilience.
Holy Basil (Tulsi)
Ayurvedic herb specifically effective for cortisol reduction and stress adaptation.
Licorice
Root that inhibits cortisol breakdown, extending its effects—useful for low cortisol states.
Maca
Maca is a cruciferous root vegetable from Peru traditionally used for fertility and sexual function. Clinical evidence supports modest benefits for sexual desire and erectile function in some populations, though effects are generally moderate.
Last reviewed: June 2026 by the Formulate Research Team. Sources cited above; methodology and scoring criteria published here.
Cite this page
Formulate Research Team. (2026, June). Reishi — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/reishi
Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.