Artichoke
Botanical
Also known as: Cynara scolymus, Cynarin, Globe artichoke, Artichoke Leaf Extract, Artichoke extract
B
Grade B💊 300-600mg standardized extract 2-3x daily🎯 7 primary uses🔗 3 synergies⚠️ Review warnings
Levels upHeart & Longevity+50 pts
Overview
Liver and digestive support herb that promotes bile flow, lowers cholesterol, and protects liver cells.
Primary Uses
Bile flowCholesterol supportLiver protectionDigestive supportDyspepsiaMotilityCholesterol
Frequently Asked About Artichoke
How much Artichoke should I take?
The typical effective range is 300-600mg standardized extract 2-3x daily. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take Artichoke?
Before meals for digestion. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take Artichoke with food?
Before fatty meals optimal.
Does Artichoke interact with medications?
Yes — known interactions include May affect CYP450 metabolism and Cholesterol medications (additive). If you take any prescription medication, talk to your doctor or pharmacist before starting Artichoke.
What does Artichoke pair well with?
Artichoke stacks well with Milk thistle, Dandelion, and Digestive enzymes — these combinations either improve absorption or work synergistically toward common goals.
Who should not take Artichoke?
Artichoke should be avoided or used with caution by people with Bile duct obstruction, Gallstones, and Daisy/ragweed allergy. Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of Artichoke?
Most people tolerate Artichoke well. The most commonly reported side effects are Gas, Bloating initially, and Allergic reactions (daisy family). Side effects are usually dose-dependent — lowering the dose often resolves them.
Dosage
Typical range
300-600mg standardized extract 2-3x daily
Timing
Before meals for digestion
With food
Before fatty meals optimal
Duration
Long-term use appropriate
Special Populations
Those with digestive issues, cholesterol concerns
Research & Studies
Search the literature now
We haven’t curated landmark studies for Artichokeyet — one-click into the primary literature here. PubMed (RCTs) is usually the highest-signal starting point.
Mechanism of Action
- • Increases bile production and flow
- • Supports cholesterol metabolism
- • Hepatoprotective effects
- • Aids fat digestion
Evidence Quality
Evidence Grade B
Good evidence for bile and cholesterol effects
Safety & Contraindications
Serious Warnings
- • May cause gallbladder attacks if gallstones present
Contraindications
- • Bile duct obstruction
- • Gallstones
- • Daisy/ragweed allergy
Common Side Effects
- • Gas
- • Bloating initially
- • Allergic reactions (daisy family)
Pregnancy & Breastfeeding
Traditionally used but limited modern data
Liver & Kidney Notes
Safe - supports liver
Interactions
💊 Medications
- • May affect CYP450 metabolism
- • Cholesterol medications (additive)
🧪 Supplements
- • Synergistic with milk thistle, dandelion
🍽️ Food & Alcohol
- • Take before meals
Stacking & Synergies
Pairs Well With
Avoid Combining With
None significant
Best Goal Synergies
Bile flowCholesterolLiver support
Buying Guide
What to Look For
- • Standardized to cynarin
- • Leaf extract
Standardization Markers
Cynarin content (2-5%)Caffeoylquinic acids
Adulteration risk
Low
Practical Notes
- • Take before meals for digestion
- • Avoid with gallstones
- • Good for fat digestion
- • Before meals for digestion
- • Good for sluggish digestion
Tags
liverbilecholesteroldigestivemotilitydyspepsiadigestion
Top Products with Artichoke
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Last reviewed: September 2026 by the Formulate Research Team. Sources cited above; methodology and scoring criteria published here.
Cite this page
Formulate Research Team. (2026, September). Artichoke — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/artichoke
Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.