Boswellia (Frankincense)
Also known as: 5-Loxin, ApresFlex, Boswellia (Indian Frankincense), Boswellia serrata, Indian frankincense
Overview
Boswellia serrata extract, standardized to boswellic acids, is traditionally used in Ayurvedic medicine and has been studied for joint health and inflammatory support. Moderate clinical evidence supports its use for musculoskeletal comfort, though effect sizes are generally modest.
Frequently Asked About Boswellia (Frankincense)
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What are the side effects of Boswellia (Frankincense)?
Dosage
2-4 weeks for effects
Joint issues, arthritis
Research & Studies
Landmark clinical studies on Boswellia (Frankincense). Each title links to a plain-English breakdown โ what the study shows, what its limitations are, and how to read around them.
- Effects of Boswellia serrata gum resin in patients with osteoarthritis of knee
8-week crossover RCT (n=30) found Boswellia serrata extract significantly reduced knee pain, increased flexion, and improved walking distance in osteoarthritis vs placebo.
- Comparative efficacy and tolerability of 5-LOXIN and AflapinAgainst osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical studySengupta K, Krishnaraju AV, Vishal AA, et al. ยท 2010 ยท International Journal of Medical SciencesRCTPubMed โ
90-day RCT (n=60) found standardized Boswellia extracts (5-LOXIN 100mg, Aflapin 100mg) improved pain and physical function in knee OA as early as 7 days, with Aflapin showing faster onset.
Mechanism of Action
- โข Inhibits 5-lipoxygenase
- โข Reduces leukotriene synthesis
- โข Protects cartilage
Evidence Quality
Good evidence for OA pain/function
Safety & Contraindications
- โข None significant
- โข None known
- โข GI upset
- โข Acid reflux
Avoid
No concerns
Interactions
- โข NSAIDs (synergistic)
- โข Immunosuppressants
- โข Curcumin
- โข Omega-3s
- โข With food
Stacking & Synergies
Buying Guide
- โข Standardized AKBA content
- โข Synergistic with curcumin
- โข ApresFlex most studied
- โข Faster acting than glucosamine
- โข AKBA form most researched
- โข AKBA form most studied
- โข Complements curcumin well
- โข Different mechanism than NSAIDs
- โข Good for IBD
- โข Often combined with curcumin
Top Products with Boswellia (Frankincense)
Highest-scored catalog products containing Boswellia (Frankincense), ranked by our scoring engine.
Browse all Boswellia (Frankincense) products โMore in Performance
Other ingredients in the Performance category.
Cite this page
Formulate Research Team. (2026, June). Boswellia (Frankincense) โ Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/boswellia
Educational content based on published research and our scoring methodology. Not medical advice โ consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.