Bromelain
Digestive
Also known as: Pineapple enzyme, Bromelain (Wound Healing), Proteolytic enzyme
B
Grade B💊 500-2000 GDU daily🎯 10 primary uses🔗 2 synergies⚠️ Review warnings
Levels upNutrition+50 pts
Overview
Pineapple-derived protease enzyme supporting protein digestion and having anti-inflammatory properties.
Primary Uses
Protein digestionInflammationSinus supportInjury recoverySwelling reductionBruisingSurgery recoveryAnti-inflammatorySinusitisWound healing
Frequently Asked About Bromelain
How much Bromelain should I take?
The typical effective range is 500-2000 GDU daily. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take Bromelain?
Between meals for inflammation; with meals for digestion. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take Bromelain with food?
Depends on goal.
Does Bromelain interact with medications?
Yes — known interactions include Blood thinners and Antibiotics enhanced. If you take any prescription medication, talk to your doctor or pharmacist before starting Bromelain.
What does Bromelain pair well with?
Bromelain stacks well with Quercetin and Turmeric — these combinations either improve absorption or work synergistically toward common goals.
Who should not take Bromelain?
Bromelain should be avoided or used with caution by people with Before surgery and Bleeding disorders. Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of Bromelain?
Most people tolerate Bromelain well. The most commonly reported side effects are GI upset and Diarrhea. Side effects are usually dose-dependent — lowering the dose often resolves them.
Dosage
Typical range
500-2000 GDU daily
Timing
Between meals for inflammation; with meals for digestion
With food
Depends on goal
Duration
Safe long-term
Special Populations
Surgery recovery, sinusitis
Research & Studies
Search the literature now
We haven’t curated landmark studies for Bromelainyet — one-click into the primary literature here. PubMed (RCTs) is usually the highest-signal starting point.
Mechanism of Action
- • Proteolytic enzyme activity
- • Anti-inflammatory effects systemic
- • Fibrinolytic properties
Evidence Quality
Evidence Grade B
Digestive and anti-inflammatory uses
Safety & Contraindications
Serious Warnings
- • Bleeding risk
Contraindications
- • Before surgery
- • Bleeding disorders
Common Side Effects
- • GI upset
- • Diarrhea
Pregnancy & Breastfeeding
Avoid high doses
Liver & Kidney Notes
Safe
Interactions
💊 Medications
- • Blood thinners
- • Antibiotics enhanced
🧪 Supplements
- • Works with quercetin
🍽️ Food & Alcohol
- • Pineapple allergy
Stacking & Synergies
Pairs Well With
Quercetin ↗Turmeric
Avoid Combining With
Blood thinners without monitoring
Best Goal Synergies
InflammationSinuses
Buying Guide
What to Look For
- • GDU units listed
Standardization Markers
GDU or MCU units
Adulteration risk
Low
Practical Notes
- • Between meals for systemic effects
- • With meals for digestion
- • Stop before surgery
- • Take between meals
- • Empty stomach for systemic effects
Tags
digestiveenzymeanti-inflammatorywoundswellingsurgeryproteinpineapple
Top Products with Bromelain
Highest-scored catalog products containing Bromelain, ranked by our scoring engine.
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More in Digestive
Other ingredients in the Digestive category.
Alpha-Galactosidase
Enzyme for breaking down gas-producing sugars in beans and cruciferous vegetables.
Amylase
Starch-digesting enzyme. Helps break down complex carbohydrates for those with carb intolerance.
Betaine HCl
Supplemental stomach acid for those with low acid production. Supports protein digestion and mineral absorption.
Digestive Enzyme Complex
Broad-spectrum enzyme blend for protein, carbohydrate, and fat digestion. Supports overall digestive comfort.
DPP-IV Enzyme
Specialized enzyme for gluten and casein breakdown. Helps with accidental exposure, not for celiac disease.
Lactase
Enzyme for lactose digestion. Essential for those with lactose intolerance to enjoy dairy.
Last reviewed: September 2026 by the Formulate Research Team. Sources cited above; methodology and scoring criteria published here.
Cite this page
Formulate Research Team. (2026, September). Bromelain — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/bromelain
Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.