DIM (Diindolylmethane)

Hormone Modulator

Also known as: Diindolylmethane, 3,3'-Diindolylmethane

Grade B

💊 100-300mg daily🎯 3 primary uses🔗 3 synergies⚠️ Review warnings

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Levels upHeart & Longevity+50 pts

Overview

Cruciferous vegetable compound that modulates estrogen metabolism, used by men and women.

Primary Uses

Estrogen metabolismHormone balanceMay support testosterone ratio

Frequently Asked About DIM (Diindolylmethane)

How much DIM (Diindolylmethane) should I take?

The typical effective range is 100-300mg daily. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.

When is the best time to take DIM (Diindolylmethane)?

With meals. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.

Should I take DIM (Diindolylmethane) with food?

Yes, fat helps absorption.

Does DIM (Diindolylmethane) interact with medications?

Yes — known interactions include Hormone therapies, Birth control, and Tamoxifen. If you take any prescription medication, talk to your doctor or pharmacist before starting DIM (Diindolylmethane).

What does DIM (Diindolylmethane) pair well with?

DIM (Diindolylmethane) stacks well with Calcium D-Glucarate, I3C, and Sulforaphane — these combinations either improve absorption or work synergistically toward common goals.

Who should not take DIM (Diindolylmethane)?

DIM (Diindolylmethane) should be avoided or used with caution by people with Hormone-sensitive cancers (discuss with oncologist). Pregnant or breastfeeding women should consult a healthcare provider before use.

What are the side effects of DIM (Diindolylmethane)?

Most people tolerate DIM (Diindolylmethane) well. The most commonly reported side effects are Headache, GI upset, and Darker urine. Side effects are usually dose-dependent — lowering the dose often resolves them.

Dosage

Typical range

100-300mg daily

Timing

With meals

With food

Yes, fat helps absorption

Duration

Can use long-term

Special Populations

Estrogen metabolism support, men on TRT, women's hormone balance

Research & Studies

Search the literature now

We haven’t curated landmark studies for DIM (Diindolylmethane)yet — one-click into the primary literature here. PubMed (RCTs) is usually the highest-signal starting point.

Search DIM (Diindolylmethane) research

PubMed (RCTs) ↗Randomized trials PubMed (all) ↗Full literature Cochrane Reviews ↗Systematic reviews Examine.com ↗Research summaries

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Mechanism of Action

• Modulates estrogen metabolism
• Shifts to beneficial 2-OH metabolites
• May reduce 16-OH and 4-OH estrogens
• Used by both men and women

Evidence Quality

Evidence Grade B

Good evidence for estrogen metabolism modulation

Safety & Contraindications

Serious Warnings

• May affect hormone-sensitive conditions

Contraindications

• Hormone-sensitive cancers (discuss with oncologist)

Common Side Effects

• Headache
• GI upset
• Darker urine
• Hormonal adjustment

Pregnancy & Breastfeeding

Avoid

Liver & Kidney Notes

May affect liver enzymes

Interactions

💊 Medications

• Hormone therapies
• Birth control
• Tamoxifen

🧪 Supplements

• Stacks with Calcium D-Glucarate

🍽️ Food & Alcohol

• With fatty meal

Stacking & Synergies

Pairs Well With

Calcium D-Glucarate ↗I3CSulforaphane ↗

Avoid Combining With

Hormone therapies without guidance

Best Goal Synergies

Estrogen metabolismHormone balance

Buying Guide

What to Look For

• Microencapsulated or with absorption enhancer
• Pure DIM

Standardization Markers

DIM contentBioPerine for absorption

Adulteration risk

Low

Practical Notes

• Modulates estrogen, doesn't just block
• Men use to manage E on TRT
• Women use for hormone balance

Related Guides

In-depth guides covering DIM (Diindolylmethane) — protocols, comparisons, and use cases.

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Last reviewed: August 2026 by the Formulate Research Team. Sources cited above; methodology and scoring criteria published here.

Cite this page

Formulate Research Team. (2026, August). DIM (Diindolylmethane) — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/dim

Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.