DIM (Diindolylmethane)
Hormone Modulator
Also known as: Diindolylmethane, 3,3'-Diindolylmethane
B
Grade B💊 100-300mg daily🎯 3 primary uses🔗 3 synergies⚠️ Review warnings
Levels upHeart & Longevity+50 pts
Overview
Cruciferous vegetable compound that modulates estrogen metabolism, used by men and women.
Primary Uses
Estrogen metabolismHormone balanceMay support testosterone ratio
Frequently Asked About DIM (Diindolylmethane)
How much DIM (Diindolylmethane) should I take?
The typical effective range is 100-300mg daily. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take DIM (Diindolylmethane)?
With meals. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take DIM (Diindolylmethane) with food?
Yes, fat helps absorption.
Does DIM (Diindolylmethane) interact with medications?
Yes — known interactions include Hormone therapies, Birth control, and Tamoxifen. If you take any prescription medication, talk to your doctor or pharmacist before starting DIM (Diindolylmethane).
What does DIM (Diindolylmethane) pair well with?
DIM (Diindolylmethane) stacks well with Calcium D-Glucarate, I3C, and Sulforaphane — these combinations either improve absorption or work synergistically toward common goals.
Who should not take DIM (Diindolylmethane)?
DIM (Diindolylmethane) should be avoided or used with caution by people with Hormone-sensitive cancers (discuss with oncologist). Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of DIM (Diindolylmethane)?
Most people tolerate DIM (Diindolylmethane) well. The most commonly reported side effects are Headache, GI upset, and Darker urine. Side effects are usually dose-dependent — lowering the dose often resolves them.
Dosage
Typical range
100-300mg daily
Timing
With meals
With food
Yes, fat helps absorption
Duration
Can use long-term
Special Populations
Estrogen metabolism support, men on TRT, women's hormone balance
Research & Studies
Search the literature now
We haven’t curated landmark studies for DIM (Diindolylmethane)yet — one-click into the primary literature here. PubMed (RCTs) is usually the highest-signal starting point.
Search DIM (Diindolylmethane) research
Mechanism of Action
- • Modulates estrogen metabolism
- • Shifts to beneficial 2-OH metabolites
- • May reduce 16-OH and 4-OH estrogens
- • Used by both men and women
Evidence Quality
Evidence Grade B
Good evidence for estrogen metabolism modulation
Safety & Contraindications
Serious Warnings
- • May affect hormone-sensitive conditions
Contraindications
- • Hormone-sensitive cancers (discuss with oncologist)
Common Side Effects
- • Headache
- • GI upset
- • Darker urine
- • Hormonal adjustment
Pregnancy & Breastfeeding
Avoid
Liver & Kidney Notes
May affect liver enzymes
Interactions
💊 Medications
- • Hormone therapies
- • Birth control
- • Tamoxifen
🧪 Supplements
- • Stacks with Calcium D-Glucarate
🍽️ Food & Alcohol
- • With fatty meal
Stacking & Synergies
Pairs Well With
Avoid Combining With
Hormone therapies without guidance
Best Goal Synergies
Estrogen metabolismHormone balance
Buying Guide
What to Look For
- • Microencapsulated or with absorption enhancer
- • Pure DIM
Standardization Markers
DIM contentBioPerine for absorption
Adulteration risk
Low
Practical Notes
- • Modulates estrogen, doesn't just block
- • Men use to manage E on TRT
- • Women use for hormone balance
Tags
estrogenhormone-balancecruciferousdetox
Related Guides
In-depth guides covering DIM (Diindolylmethane) — protocols, comparisons, and use cases.
Last reviewed: June 2026 by the Formulate Research Team. Sources cited above; methodology and scoring criteria published here.
Cite this page
Formulate Research Team. (2026, June). DIM (Diindolylmethane) — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/dim
Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.