Sulforaphane

Antioxidant

Also known as: Broccoli extract, Broccoli sprout extract, Glucoraphanin, Glucoraphanin (precursor), Glucoraphanin + myrosinase

Grade B

💊 10-50 mg sulforaphane or equivalent🎯 4 primary uses🔗 2 synergies⚠️ Review warnings

Overview

Potent Nrf2 activator from broccoli sprouts. Induces phase II detoxification and has anticancer properties.

Primary Uses

DetoxificationAnticancerNrf2 activationInflammation

Dosage

Typical range

10-50 mg sulforaphane or equivalent

Timing

Any time

With food

Optional

Dose Tiers

Moderate

10-30 mg/day

Optimal

30-90 mg/day

Therapeutic

100-200 mg/day

Upper Limit

No established UL

Duration

Safe long-term

Special Populations

Detox, cancer prevention

Mechanism of Action

• Activates Nrf2 pathway
• Induces phase II detox enzymes
• NF-kB inhibitor

Evidence Quality

Evidence Grade B

Powerful Nrf2 activator

Safety & Contraindications

Serious Warnings

• None

Contraindications

• None

Common Side Effects

• Gas
• Bloating

Pregnancy & Breastfeeding

Consult healthcare provider

Liver & Kidney Notes

Supports liver detox

Interactions

💊 Medications

• May affect drug metabolism

🧪 Supplements

• Works with other detox support

🍽️ Food & Alcohol

• Broccoli sprouts best source

Stacking & Synergies

Pairs Well With

NACMilk thistle

Avoid Combining With

None

Best Goal Synergies

DetoxCancer prevention

Buying Guide

What to Look For

• Myrosinase enzyme included

Standardization Markers

Sulforaphane yieldMyrosinase included

Adulteration risk

Moderate

Practical Notes

• Fresh broccoli sprouts most potent
• Needs myrosinase enzyme

Frequently Asked About Sulforaphane

How much Sulforaphane should I take?

The typical effective range is 30-90 mg/day. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.

When is the best time to take Sulforaphane?

Any time. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.

Should I take Sulforaphane with food?

Optional.

Does Sulforaphane interact with medications?

Yes — known interactions include May affect drug metabolism. If you take any prescription medication, talk to your doctor or pharmacist before starting Sulforaphane.

What does Sulforaphane pair well with?

Sulforaphane stacks well with NAC and Milk thistle — these combinations either improve absorption or work synergistically toward common goals.

Who should not take Sulforaphane?

Sulforaphane should be avoided or used with caution by people with None. Pregnant or breastfeeding women should consult a healthcare provider before use.

What are the side effects of Sulforaphane?

Most people tolerate Sulforaphane well. The most commonly reported side effects are Gas and Bloating. Side effects are usually dose-dependent — lowering the dose often resolves them.

Related Guides

In-depth guides covering Sulforaphane — protocols, comparisons, and use cases.

Beginner Longevity Supplement Stack↗

Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.