Sulforaphane
Antioxidant
Also known as: Broccoli extract, Broccoli sprout extract, Glucoraphanin, Glucoraphanin (precursor), Glucoraphanin + myrosinase
B
Grade B💊 10-50 mg sulforaphane or equivalent🎯 4 primary uses🔗 2 synergies⚠️ Review warnings
Levels upHeart & Longevity+50 pts
Overview
Potent Nrf2 activator from broccoli sprouts. Induces phase II detoxification and has anticancer properties.
Primary Uses
DetoxificationAnticancerNrf2 activationInflammation
Frequently Asked About Sulforaphane
How much Sulforaphane should I take?
The typical effective range is 30-90 mg/day. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take Sulforaphane?
Any time. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take Sulforaphane with food?
Optional.
Does Sulforaphane interact with medications?
Yes — known interactions include May affect drug metabolism. If you take any prescription medication, talk to your doctor or pharmacist before starting Sulforaphane.
What does Sulforaphane pair well with?
Sulforaphane stacks well with NAC and Milk thistle — these combinations either improve absorption or work synergistically toward common goals.
Who should not take Sulforaphane?
Sulforaphane should be avoided or used with caution by people with None. Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of Sulforaphane?
Most people tolerate Sulforaphane well. The most commonly reported side effects are Gas and Bloating. Side effects are usually dose-dependent — lowering the dose often resolves them.
Dosage
Typical range
10-50 mg sulforaphane or equivalent
Timing
Any time
With food
Optional
Dose Tiers
Moderate
10-30 mg/day
Optimal
30-90 mg/day
Therapeutic
100-200 mg/day
Upper Limit
No established UL
Duration
Safe long-term
Special Populations
Detox, cancer prevention
Research & Studies
Search the literature now
We haven’t curated landmark studies for Sulforaphaneyet — one-click into the primary literature here. PubMed (RCTs) is usually the highest-signal starting point.
Mechanism of Action
- • Activates Nrf2 pathway
- • Induces phase II detox enzymes
- • NF-kB inhibitor
Evidence Quality
Evidence Grade B
Powerful Nrf2 activator
Safety & Contraindications
Serious Warnings
- • None
Contraindications
- • None
Common Side Effects
- • Gas
- • Bloating
Pregnancy & Breastfeeding
Consult healthcare provider
Liver & Kidney Notes
Supports liver detox
Interactions
💊 Medications
- • May affect drug metabolism
🧪 Supplements
- • Works with other detox support
🍽️ Food & Alcohol
- • Broccoli sprouts best source
Stacking & Synergies
Buying Guide
What to Look For
- • Myrosinase enzyme included
Standardization Markers
Sulforaphane yieldMyrosinase included
Adulteration risk
Moderate
Practical Notes
- • Fresh broccoli sprouts most potent
- • Needs myrosinase enzyme
Tags
antioxidantdetoxNrf2cruciferous
Top Products with Sulforaphane
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Related Guides
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More in Antioxidant
Other ingredients in the Antioxidant category.
Alpha-Lipoic Acid (ALA)
Universal antioxidant working in both water and fat. Regenerates other antioxidants and supports blood sugar metabolism.
Astaxanthin
Astaxanthin is a carotenoid with potent antioxidant and anti-inflammatory properties, naturally present in krill and microalgae. It crosses the blood–brain barrier and may support eye, skin, and cellular health.
Broccoli
Broccoli powder is a whole-food derived ingredient rich in sulforaphane, glucosinolates, and polyphenols that support antioxidant and detoxification pathways. Evidence supports potential benefits for cellular health and inflammatory response, though most human research uses fresh broccoli or concentrated extracts rather than powder forms.
C60 (Carbon 60 Fullerene)
Spherical carbon molecule with potent antioxidant properties in olive oil. Controversial with limited human data despite promising rodent longevity studies.
Citrus Bioflavonoids
Plant compounds from citrus fruits that enhance vitamin C absorption and provide antioxidant, anti-inflammatory, and vascular support benefits.
CoQ10 (Ubiquinone/Ubiquinol)
Ubiquinol is the reduced, active form of CoQ10 that plays a critical role in cellular energy production via the mitochondrial electron transport chain and serves as a lipid-soluble antioxidant. It is more bioavailable than standard ubiquinone (oxidized CoQ10), particularly in aging populations.
Last reviewed: June 2026 by the Formulate Research Team. Sources cited above; methodology and scoring criteria published here.
Cite this page
Formulate Research Team. (2026, June). Sulforaphane — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/sulforaphane
Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.