Diosmin/Hesperidin

Cardiovascular

Also known as: Micronized diosmin, Daflon

Grade A

💊 500-1000mg daily🎯 4 primary uses🔗 3 synergies⚠️ Review warnings

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Levels upHeart & Longevity+50 pts

Overview

Citrus flavonoids for venous and lymphatic health. Popular in Europe for vein support.

Primary Uses

Venous healthHemorrhoidsLeg swellingLymphatic

Frequently Asked About Diosmin/Hesperidin

How much Diosmin/Hesperidin should I take?

The typical effective range is 500-1000mg daily. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.

When is the best time to take Diosmin/Hesperidin?

With meals. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.

Should I take Diosmin/Hesperidin with food?

Yes.

Does Diosmin/Hesperidin interact with medications?

Yes — known interactions include Blood thinners (mild). If you take any prescription medication, talk to your doctor or pharmacist before starting Diosmin/Hesperidin.

What does Diosmin/Hesperidin pair well with?

Diosmin/Hesperidin stacks well with Horse chestnut, Grape seed, and Vitamin C — these combinations either improve absorption or work synergistically toward common goals.

Who should not take Diosmin/Hesperidin?

Diosmin/Hesperidin should be avoided or used with caution by people with None. Pregnant or breastfeeding women should consult a healthcare provider before use.

What are the side effects of Diosmin/Hesperidin?

Most people tolerate Diosmin/Hesperidin well. The most commonly reported side effects are GI upset and Headache. Side effects are usually dose-dependent — lowering the dose often resolves them.

Dosage

Typical range

500-1000mg daily

Timing

With meals

With food

Yes

Duration

Ongoing or cycling

Special Populations

Venous insufficiency, hemorrhoids, swelling

Research & Studies

Search the literature now

We haven’t curated landmark studies for Diosmin/Hesperidinyet — one-click into the primary literature here. PubMed (RCTs) is usually the highest-signal starting point.

Search Diosmin/Hesperidin research

PubMed (RCTs) ↗Randomized trials PubMed (all) ↗Full literature Cochrane Reviews ↗Systematic reviews Examine.com ↗Research summaries

Browse all curated studies →

Mechanism of Action

• Strengthens vein walls
• Improves lymphatic drainage
• Anti-inflammatory

Evidence Quality

Evidence Grade A

European venous medication

Safety & Contraindications

Serious Warnings

• None

Contraindications

• None

Common Side Effects

• GI upset
• Headache

Pregnancy & Breastfeeding

Used in pregnancy for hemorrhoids (consult doctor)

Liver & Kidney Notes

Safe

Interactions

💊 Medications

• Blood thinners (mild)

🧪 Supplements

• Works with horse chestnut, vitamin C

🍽️ Food & Alcohol

• With food

Stacking & Synergies

Pairs Well With

Horse chestnut ↗Grape seedVitamin C ↗

Avoid Combining With

None

Best Goal Synergies

Venous healthHemorrhoids

Buying Guide

What to Look For

• Micronized
• 90% diosmin typical

Standardization Markers

Diosmin contentMicronized form

Adulteration risk

Low

Practical Notes

• Prescription in some countries
• Popular for hemorrhoids

More in Cardiovascular

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Beet

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Butcher's Broom

Traditional remedy for poor circulation and venous health. Supports leg circulation.

Ginkgo Biloba (Circulation Focus)

Improves microcirculation, especially to extremities and brain. Traditional circulation herb.

Grape Seed Extract

Rich in OPCs for vascular health. Strengthens capillaries and supports circulation.

Horse Chestnut Extract

Horse chestnut extract, standardized to escin, is traditionally used to support venous circulation and reduce symptoms of chronic venous insufficiency. Multiple clinical trials support its efficacy for reducing leg swelling, heaviness, and pain related to venous dysfunction.

Browse all Cardiovascular ingredients →

Last reviewed: September 2026 by the Formulate Research Team. Sources cited above; methodology and scoring criteria published here.

Cite this page

Formulate Research Team. (2026, September). Diosmin/Hesperidin — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/diosmin

Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.