Diosmin/Hesperidin
Cardiovascular
Also known as: Micronized diosmin, Daflon
A
Grade A💊 500-1000mg daily🎯 4 primary uses🔗 3 synergies⚠️ Review warnings
Levels upVitality+50 pts
Overview
Citrus flavonoids for venous and lymphatic health. Popular in Europe for vein support.
Primary Uses
Venous healthHemorrhoidsLeg swellingLymphatic
Frequently Asked About Diosmin/Hesperidin
How much Diosmin/Hesperidin should I take?
The typical effective range is 500-1000mg daily. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take Diosmin/Hesperidin?
With meals. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take Diosmin/Hesperidin with food?
Yes.
Does Diosmin/Hesperidin interact with medications?
Yes — known interactions include Blood thinners (mild). If you take any prescription medication, talk to your doctor or pharmacist before starting Diosmin/Hesperidin.
What does Diosmin/Hesperidin pair well with?
Diosmin/Hesperidin stacks well with Horse chestnut, Grape seed, and Vitamin C — these combinations either improve absorption or work synergistically toward common goals.
Who should not take Diosmin/Hesperidin?
Diosmin/Hesperidin should be avoided or used with caution by people with None. Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of Diosmin/Hesperidin?
Most people tolerate Diosmin/Hesperidin well. The most commonly reported side effects are GI upset and Headache. Side effects are usually dose-dependent — lowering the dose often resolves them.
Dosage
Typical range
500-1000mg daily
Timing
With meals
With food
Yes
Duration
Ongoing or cycling
Special Populations
Venous insufficiency, hemorrhoids, swelling
Research & Studies
Search the literature now
We haven’t curated landmark studies for Diosmin/Hesperidinyet — one-click into the primary literature here. PubMed (RCTs) is usually the highest-signal starting point.
Search Diosmin/Hesperidin research
Mechanism of Action
- • Strengthens vein walls
- • Improves lymphatic drainage
- • Anti-inflammatory
Evidence Quality
Evidence Grade A
European venous medication
Safety & Contraindications
Serious Warnings
- • None
Contraindications
- • None
Common Side Effects
- • GI upset
- • Headache
Pregnancy & Breastfeeding
Used in pregnancy for hemorrhoids (consult doctor)
Liver & Kidney Notes
Safe
Interactions
💊 Medications
- • Blood thinners (mild)
🧪 Supplements
- • Works with horse chestnut, vitamin C
🍽️ Food & Alcohol
- • With food
Stacking & Synergies
Pairs Well With
Avoid Combining With
None
Best Goal Synergies
Venous healthHemorrhoids
Buying Guide
What to Look For
- • Micronized
- • 90% diosmin typical
Standardization Markers
Diosmin contentMicronized form
Adulteration risk
Low
Practical Notes
- • Prescription in some countries
- • Popular for hemorrhoids
Tags
cardiovascularveinscitruslymphatic
More in Cardiovascular
Other ingredients in the Cardiovascular category.
Beet
Beet root powder is derived from the root of Beta vulgaris and contains bioactive compounds including betalains and nitrates, which may support cardiovascular function and exercise performance. Evidence supports benefits for blood pressure regulation and endothelial function, particularly in nitrate-sensitive contexts.
Butcher's Broom
Traditional remedy for poor circulation and venous health. Supports leg circulation.
Ginkgo Biloba (Circulation Focus)
Improves microcirculation, especially to extremities and brain. Traditional circulation herb.
Grape Seed Extract
Rich in OPCs for vascular health. Strengthens capillaries and supports circulation.
Horse Chestnut Extract
Horse chestnut extract, standardized to escin, is traditionally used to support venous circulation and reduce symptoms of chronic venous insufficiency. Multiple clinical trials support its efficacy for reducing leg swelling, heaviness, and pain related to venous dysfunction.
Last reviewed: June 2026 by the Formulate Research Team. Sources cited above; methodology and scoring criteria published here.
Cite this page
Formulate Research Team. (2026, June). Diosmin/Hesperidin — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/diosmin
Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.