Manganese
Mineral
Also known as: Manganese citrate, Manganese glycinate, Manganese sulfate, Mn, Manganese gluconate
B
Grade B💊 2-5 mg daily🎯 6 primary uses🔗 1 synergy⚠️ Review warnings
Levels upNutrition+50 pts
Overview
Trace mineral supporting bone formation, antioxidant defenses (SOD), and glucose metabolism. Most people get adequate amounts from diet.
Primary Uses
Bone healthAntioxidant (SOD)Blood sugar supportAntioxidant enzymeMetabolismImmune cell protection
Frequently Asked About Manganese
How much Manganese should I take?
The typical effective range is 2-5 mg daily. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take Manganese?
Any. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take Manganese with food?
Optional.
Does Manganese interact with medications?
Yes — known interactions include None significant. If you take any prescription medication, talk to your doctor or pharmacist before starting Manganese.
What does Manganese pair well with?
Manganese stacks well with Bone support nutrients — these combinations either improve absorption or work synergistically toward common goals.
Who should not take Manganese?
Manganese should be avoided or used with caution by people with Liver disease. Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of Manganese?
Most people tolerate Manganese well. The most commonly reported side effects are Well tolerated. Side effects are usually dose-dependent — lowering the dose often resolves them.
Dosage
Typical range
2-5 mg daily
Timing
Any
With food
Optional
Duration
Usually adequate from diet
Special Populations
Rarely needed as supplement
Research & Studies
Search the literature now
We haven’t curated landmark studies for Manganeseyet — one-click into the primary literature here. PubMed (RCTs) is usually the highest-signal starting point.
Mechanism of Action
- • Cofactor for superoxide dismutase (SOD)
- • Essential for bone formation
- • Involved in glucose metabolism
Evidence Quality
Evidence Grade B
Essential trace mineral
Safety & Contraindications
Serious Warnings
- • Neurotoxicity at high doses
- • Accumulates
Contraindications
- • Liver disease
Common Side Effects
- • Well tolerated
Pregnancy & Breastfeeding
Consult healthcare provider
Liver & Kidney Notes
Excreted via bile, avoid liver disease
Interactions
💊 Medications
- • None significant
🧪 Supplements
- • Competes with iron, calcium
🍽️ Food & Alcohol
- • No interactions
Stacking & Synergies
Pairs Well With
Bone support nutrients
Avoid Combining With
High doses
Best Goal Synergies
Bone health as part of complex
Buying Guide
What to Look For
- • Low dose (2-5mg)
Standardization Markers
mg manganese
Adulteration risk
Low
Practical Notes
- • Usually adequate from diet
- • Toxicity concern at high doses
- • Diet usually provides enough
- • In most multivitamins
- • No need for separate supplement usually
Tags
mineraltrace mineralantioxidantenzymetrace
Top Products with Manganese
Highest-scored catalog products containing Manganese, ranked by our scoring engine.
MediClear-SGS™ - VanillaThorne95
Basic Nutrients 2/DayThorne93
Basic PrenatalThorne93
MediClear Plus®Thorne93
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Last reviewed: June 2026 by the Formulate Research Team. Sources cited above; methodology and scoring criteria published here.
Cite this page
Formulate Research Team. (2026, June). Manganese — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/manganese
Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.