Interaction Checker

Check interactions

Add your supplements, foods, meals — and any medications you take — to see how they interact. Findings are grouped by severity: what to avoid, what needs care or timing, and what actually works better together.

Amino Replete

Add more (1/12)

Add a medication you take (optional)

Caution

19 · Combine carefully — read the note

Caution

Vitamin B6Levodopa

Vitamin B6: Levodopa

Known interaction

Caution

Vitamin B6Some seizure meds

Vitamin B6: Some seizure meds

Known interaction

Caution

L-HistidineAntihistamines may interact

L-Histidine: Antihistamines may interact

Known interaction

Caution

L-IsoleucineDiabetes medications (affects blood sugar)

L-Isoleucine: Diabetes medications (affects blood sugar)

Known interaction

Caution

LeucineNone significant

Leucine: None significant

Known interaction

Caution

L-LysineAminoglycoside antibiotics

L-Lysine: Aminoglycoside antibiotics

Known interaction

Caution

L-PhenylalanineMAOIs - dangerous

L-Phenylalanine: MAOIs - dangerous

Known interaction

Caution

L-PhenylalanineLevodopa

L-Phenylalanine: Levodopa

Known interaction

Caution

L-ThreonineNone significant

L-Threonine: None significant

Known interaction

Caution

L-ValineMay affect blood sugar

L-Valine: May affect blood sugar

Known interaction

Caution

L-ArginineBlood pressure meds

L-Arginine: Blood pressure meds

Known interaction

Caution

L-ArginineViagra/Cialis

L-Arginine: Viagra/Cialis

Known interaction

Caution

L-GlutamineLactulose

L-Glutamine: Lactulose

Known interaction

Caution

L-GlutamineChemotherapy drugs

L-Glutamine: Chemotherapy drugs

Known interaction

Caution

GlycineClozapine interaction theoretically

Glycine: Clozapine interaction theoretically

Known interaction

Caution

L-TyrosineMAOIs contraindicated

L-Tyrosine: MAOIs contraindicated

Known interaction

Caution

L-TyrosineThyroid meds

L-Tyrosine: Thyroid meds

Known interaction

Caution

L-TryptophanSSRIs, MAOIs - serotonin syndrome risk

L-Tryptophan: SSRIs, MAOIs - serotonin syndrome risk

Known interaction

Caution

L-ArginineL-Lysine

L-Arginine: Lysine (competes)

Stacking note

Works well together

4 · Beneficial pairing

Works well together

L-IsoleucineLeucine

L-Isoleucine pairs well with Leucine.

Stacking note

Works well together

L-IsoleucineL-Valine

L-Isoleucine pairs well with L-Valine.

Stacking note

Works well together

L-ValineLeucine

L-Valine pairs well with Leucine.

Stacking note

Works well together

L-TryptophanVitamin B6

L-Tryptophan pairs well with Vitamin B6.

Stacking note

Not medical advice. This tool surfaces well-established and known interactions from our reference data and curated rules. It is not exhaustive, can’t see your full health picture, and an absence of findings does not mean a combination is safe. Always consult a doctor or pharmacist about your supplements and medications.