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Biochemical Pathway

Gut Microbiome

Prebiotic fibre + live cultures → short-chain fatty acids (butyrate)

Your gut bacteria are a metabolic organ in their own right, and what you feed them decides what they make. The pathway runs as a sequence — prebiotic → probiotic → postbiotic. Prebiotic fibre (inulin, resistant starch, β-glucan) and polyphenols are the substrate; the live cultures in fermented foods (yogurt, kefir, kimchi, sauerkraut, kombucha, miso, tempeh) are the bacteria themselves, dosed in colony-forming units (CFU) rather than milligrams. When those bacteria ferment fibre they produce postbiotics — short-chain fatty acids like butyrate, propionate, and acetate — which fuel the cells lining the colon, tighten the gut barrier, calm inflammation, and signal outward to the immune system and the brain along the gut-brain axis. Fibre diversity and regular fermented foods build the community; a low-fibre, ultra-processed diet and broad-spectrum antibiotics tear it down. There is no RDA for CFU or prebiotic grams, so this pathway scores the one input that does have a target — fibre — and surfaces the live cultures and polyphenols beside it as named contributors.

See your coverage for the Gut Microbiome pathway

How your supplements + diet feed this pathway right now — the cofactors driving it, where the gaps are, and your own lab readouts.

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Primary cofactors

The load-bearing nutrients — if these are deficient, this pathway slows down. Click any to see daily targets, food sources, and supplements that supply it.

Additional cofactors

Nutrients that contribute to this pathway but aren’t the single load-bearing inputs.

Biomarkers on this pathway

Lab markers that report on how well this pathway is running. When one of these is out of range, this pathway is often where the upstream issue lives.

🩸 hs-CRP

Save a lab session under My Journey → Biomarkers to see your own values for these.

Body systems that depend on this pathway
Related pathways

Pathways that share a load-bearing cofactor with this one.