Apigenin
Sleep
Also known as: 4',5,7-trihydroxyflavone, Chamomile extract, Chamomile flavonoid
B
Grade B💊 50-300 mg before bed🎯 3 primary uses🔗 2 synergies⚠️ Review warnings
Levels upSleep+50 pts
Overview
Chamomile flavonoid with mild sedative and anti-anxiety effects. Binds GABA receptors.
Primary Uses
SleepAnxietyRelaxation
Frequently Asked About Apigenin
How much Apigenin should I take?
The typical effective range is 50-300 mg before bed. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take Apigenin?
Evening. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take Apigenin with food?
Optional.
Does Apigenin interact with medications?
Yes — known interactions include CNS depressants and Blood thinners mild. If you take any prescription medication, talk to your doctor or pharmacist before starting Apigenin.
What does Apigenin pair well with?
Apigenin stacks well with Magnesium threonate and L-theanine — these combinations either improve absorption or work synergistically toward common goals.
Who should not take Apigenin?
Apigenin should be avoided or used with caution by people with Chamomile/ragweed allergy. Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of Apigenin?
Most people tolerate Apigenin well. The most commonly reported side effects are Drowsiness and Allergic reaction if chamomile-sensitive. Side effects are usually dose-dependent — lowering the dose often resolves them.
Dosage
Typical range
50-300 mg before bed
Timing
Evening
With food
Optional
Duration
Safe long-term
Special Populations
Sleep, mild anxiety
Research & Studies
Search the literature now
We haven’t curated landmark studies for Apigeninyet — one-click into the primary literature here. PubMed (RCTs) is usually the highest-signal starting point.
Mechanism of Action
- • GABA-A receptor modulation
- • CD38 inhibition (NAD+ sparing)
- • Anti-inflammatory
Evidence Quality
Evidence Grade B
Chamomile's active compound
Safety & Contraindications
Serious Warnings
- • Ragweed allergy cross-reaction
Contraindications
- • Chamomile/ragweed allergy
Common Side Effects
- • Drowsiness
- • Allergic reaction if chamomile-sensitive
Pregnancy & Breastfeeding
Consult healthcare provider
Liver & Kidney Notes
Safe
Interactions
💊 Medications
- • CNS depressants
- • Blood thinners mild
🧪 Supplements
- • Works with magnesium
🍽️ Food & Alcohol
- • No interactions
Stacking & Synergies
Pairs Well With
Avoid Combining With
None
Best Goal Synergies
Gentle sleep support
Buying Guide
What to Look For
- • Purity
Standardization Markers
Apigenin content
Adulteration risk
Low
Practical Notes
- • Also may help preserve NAD+
- • Very gentle effects
Tags
sleepanxietyflavonoidgentle
Top Products with Apigenin
Highest-scored catalog products containing Apigenin, ranked by our scoring engine.
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More in Sleep
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Mild sedative and anxiolytic herb in the poppy family. Distinct from opium poppy — no opioid alkaloids.
CBD Oil
Non-psychoactive cannabis compound for anxiety, pain, and sleep. Legal status varies.
Chamomile
Chamomile is a traditional herbal remedy with mild sedative and anxiolytic properties, supported by moderate clinical evidence for sleep quality and relaxation. Multiple studies suggest benefits for anxiety and digestive comfort, though effects are generally modest.
GABA (Supplemental)
Inhibitory neurotransmitter supplement with debated BBB penetration. May work peripherally for relaxation.
Honokiol
Isolated magnolia bark compound with potent GABA-A effects. More specific than whole bark.
Hops
Traditional sleep and anxiety herb from the brewing plant. Most consistently effective when combined with valerian.
Last reviewed: June 2026 by the Formulate Research Team. Sources cited above; methodology and scoring criteria published here.
Cite this page
Formulate Research Team. (2026, June). Apigenin — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/apigenin
Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.