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DIM (Diindolylmethane)

Phytonutrient

Also known as: Cruciferous compound, Cruciferous extract, DIM, Diindolylmethane

B
Grade B
💊 100-200mg enhanced DIM daily🎯 4 primary uses🔗 3 synergies⚠️ Review warnings
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Levels upNutrition+50 pts

Overview

Cruciferous compound that supports healthy estrogen metabolism and liver detoxification of hormones.

Primary Uses
Estrogen metabolismHormone detoxHormonal balanceCancer prevention

Frequently Asked About DIM (Diindolylmethane)

How much DIM (Diindolylmethane) should I take?
The typical effective range is 100-200mg enhanced DIM daily. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take DIM (Diindolylmethane)?
With meals. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take DIM (Diindolylmethane) with food?
Yes, enhances absorption.
Does DIM (Diindolylmethane) interact with medications?
Yes — known interactions include May affect hormone therapies and Birth control (theoretical). If you take any prescription medication, talk to your doctor or pharmacist before starting DIM (Diindolylmethane).
What does DIM (Diindolylmethane) pair well with?
DIM (Diindolylmethane) stacks well with Calcium D-glucarate, Sulforaphane, and B vitamins — these combinations either improve absorption or work synergistically toward common goals.
Who should not take DIM (Diindolylmethane)?
DIM (Diindolylmethane) should be avoided or used with caution by people with Hormone-sensitive cancers (consult oncologist). Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of DIM (Diindolylmethane)?
Most people tolerate DIM (Diindolylmethane) well. The most commonly reported side effects are GI upset, Headache, and Darkened urine. Side effects are usually dose-dependent — lowering the dose often resolves them.

Dosage

Typical range
100-200mg enhanced DIM daily
Timing
With meals
With food
Yes, enhances absorption
Duration

Long-term use appropriate

Special Populations

Those with estrogen dominance, hormonal concerns, men on TRT

Research & Studies

Search the literature now

We haven’t curated landmark studies for DIM (Diindolylmethane)yet — one-click into the primary literature here. PubMed (RCTs) is usually the highest-signal starting point.

Search DIM (Diindolylmethane) research
PubMed (RCTs) ↗Randomized trialsPubMed (all) ↗Full literatureCochrane Reviews ↗Systematic reviewsExamine.com ↗Research summaries
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Mechanism of Action

  • • Shifts estrogen to favorable metabolites (2-OH)
  • • Supports liver hormone clearance
  • • May have anti-cancer effects
  • • Derived from I3C in cruciferous vegetables

Evidence Quality

Evidence Grade B

Good evidence for estrogen metabolite ratios

Safety & Contraindications

Serious Warnings
  • • May affect hormone-sensitive conditions
Contraindications
  • • Hormone-sensitive cancers (consult oncologist)
Common Side Effects
  • • GI upset
  • • Headache
  • • Darkened urine
Pregnancy & Breastfeeding

Avoid - affects hormones

Liver & Kidney Notes

Safe - supports liver

Interactions

💊 Medications
  • • May affect hormone therapies
  • • Birth control (theoretical)
🧪 Supplements
  • • Synergistic with calcium d-glucarate, sulforaphane
🍽️ Food & Alcohol
  • • Take with food

Stacking & Synergies

Avoid Combining With
Hormone therapies without monitoring
Best Goal Synergies
Estrogen balanceHormone detox

Buying Guide

What to Look For
  • • Enhanced absorption form
  • • BioResponse DIM or equivalent
Standardization Markers
DIM contentAbsorption enhancement
Adulteration risk
Low
Practical Notes
  • • Enhanced absorption forms work better
  • • Supports healthy 2-OH estrogen
  • • Often used with calcium d-glucarate
Tags
hormoneestrogendetoxcruciferous

Top Products with DIM (Diindolylmethane)

Highest-scored catalog products containing DIM (Diindolylmethane), ranked by our scoring engine.

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Related Guides

In-depth guides covering DIM (Diindolylmethane) — protocols, comparisons, and use cases.

More in Phytonutrient

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Sulforaphane Glucosinolate (SGS)
Stable sulforaphane precursor from broccoli seeds. Powerful Nrf2 activator for detoxification and cellular protection.
A
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Last reviewed: June 2026 by the Formulate Research Team. Sources cited above; methodology and scoring criteria published here.
Cite this page
Formulate Research Team. (2026, June). DIM (Diindolylmethane) — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/diindolylmethane

Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.