Sulforaphane Glucosinolate (SGS)

Phytonutrient

Also known as: SGS, Glucosinolate, Sulforaphane glucosinolate, Broccoli seed extract

Grade A

💊 30-100mg glucosinolate daily🎯 4 primary uses🔗 3 synergies⚠️ Review warnings

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Levels upNutrition+50 pts

Overview

Stable sulforaphane precursor from broccoli seeds. Powerful Nrf2 activator for detoxification and cellular protection.

Primary Uses

Nrf2 activationDetoxificationCellular protectionPhase 2 enzyme induction

Frequently Asked About Sulforaphane Glucosinolate (SGS)

How much Sulforaphane Glucosinolate (SGS) should I take?

The typical effective range is 30-100mg glucosinolate daily. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.

When is the best time to take Sulforaphane Glucosinolate (SGS)?

With meals. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.

Should I take Sulforaphane Glucosinolate (SGS) with food?

Yes.

Does Sulforaphane Glucosinolate (SGS) interact with medications?

Yes — known interactions include May affect drug metabolism. If you take any prescription medication, talk to your doctor or pharmacist before starting Sulforaphane Glucosinolate (SGS).

What does Sulforaphane Glucosinolate (SGS) pair well with?

Sulforaphane Glucosinolate (SGS) stacks well with NAC, Milk thistle, and DIM — these combinations either improve absorption or work synergistically toward common goals.

Who should not take Sulforaphane Glucosinolate (SGS)?

Sulforaphane Glucosinolate (SGS) should be avoided or used with caution by people with Thyroid issues (high doses). Pregnant or breastfeeding women should consult a healthcare provider before use.

What are the side effects of Sulforaphane Glucosinolate (SGS)?

Most people tolerate Sulforaphane Glucosinolate (SGS) well. The most commonly reported side effects are GI upset. Side effects are usually dose-dependent — lowering the dose often resolves them.

Dosage

Typical range

30-100mg glucosinolate daily

Timing

With meals

With food

Yes

Duration

Safe long-term

Special Populations

Detox support

Research & Studies

Search the literature now

We haven’t curated landmark studies for Sulforaphane Glucosinolate (SGS)yet — one-click into the primary literature here. PubMed (RCTs) is usually the highest-signal starting point.

Search Sulforaphane Glucosinolate (SGS) research

PubMed (RCTs) ↗Randomized trials PubMed (all) ↗Full literature Cochrane Reviews ↗Systematic reviews Examine.com ↗Research summaries

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Mechanism of Action

• Converts to sulforaphane
• Activates Nrf2 pathway
• Induces phase 2 detox enzymes
• Supports glutathione

Evidence Quality

Evidence Grade A

Strong evidence for Nrf2 activation and detox support

Safety & Contraindications

Serious Warnings

• May affect thyroid at very high doses

Contraindications

• Thyroid issues (high doses)

Common Side Effects

• GI upset

Pregnancy & Breastfeeding

Consult healthcare provider

Liver & Kidney Notes

Supports liver

Interactions

💊 Medications

• May affect drug metabolism

🧪 Supplements

• Works with NAC, glutathione support

🍽️ Food & Alcohol

• With food

Stacking & Synergies

Pairs Well With

NAC ↗Milk thistle ↗DIM ↗

Avoid Combining With

None

Best Goal Synergies

DetoxificationNrf2 activation

Buying Guide

What to Look For

• Standardized SGS content

Standardization Markers

SGS contentGlucosinolate %

Adulteration risk

Low

Practical Notes

• Stable form of sulforaphane precursor
• Used in MediClear formulas

More in Phytonutrient

Other ingredients in the Phytonutrient category.

DIM (Diindolylmethane)

Cruciferous compound that supports healthy estrogen metabolism and liver detoxification of hormones.

Browse all Phytonutrient ingredients →

Last reviewed: August 2026 by the Formulate Research Team. Sources cited above; methodology and scoring criteria published here.

Cite this page

Formulate Research Team. (2026, August). Sulforaphane Glucosinolate (SGS) — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/sgs-sulforaphane-glucosinolate

Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.

Formulate Research Team. (2026, August). Sulforaphane Glucosinolate (SGS) — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/sgs-sulforaphane-glucosinolate