Ergothioneine
Antioxidant
Also known as: Ergo, L-ergothioneine, EGT
B
Grade B💊 5-25mg daily🎯 4 primary uses🔗 3 synergies⚠️ Review warnings
Levels upVitality+50 pts
Overview
Longevity amino acid with unique cellular uptake via dedicated transporter. Potent antioxidant concentrated in mitochondria, potential longevity compound.
Primary Uses
LongevityAntioxidantMitochondrial protectionNeuroprotection
Frequently Asked About Ergothioneine
How much Ergothioneine should I take?
The typical effective range is 5-25mg daily. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take Ergothioneine?
Any time. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take Ergothioneine with food?
Optional.
Does Ergothioneine interact with medications?
Yes — known interactions include None known. If you take any prescription medication, talk to your doctor or pharmacist before starting Ergothioneine.
What does Ergothioneine pair well with?
Ergothioneine stacks well with PQQ, CoQ10, and NMN — these combinations either improve absorption or work synergistically toward common goals.
Who should not take Ergothioneine?
Ergothioneine should be avoided or used with caution by people with None established. Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of Ergothioneine?
Most people tolerate Ergothioneine well. The most commonly reported side effects are Very well tolerated. Side effects are usually dose-dependent — lowering the dose often resolves them.
Dosage
Typical range
5-25mg daily
Timing
Any time
With food
Optional
Duration
Safe long-term
Special Populations
Longevity-focused, antioxidant support
Research & Studies
Search the literature now
We haven’t curated landmark studies for Ergothioneineyet — one-click into the primary literature here. PubMed (RCTs) is usually the highest-signal starting point.
Mechanism of Action
- • Dedicated cellular transporter (OCTN1)
- • Concentrates in mitochondria
- • Potent antioxidant
- • Levels decline with age
Evidence Quality
Evidence Grade B
Emerging longevity research, dedicated transporter suggests importance
Safety & Contraindications
Serious Warnings
- • None known
Contraindications
- • None established
Common Side Effects
- • Very well tolerated
Pregnancy & Breastfeeding
Avoid, insufficient data
Liver & Kidney Notes
Safe
Interactions
💊 Medications
- • None known
🧪 Supplements
- • Works with other longevity compounds
🍽️ Food & Alcohol
- • Mushrooms are primary source
Stacking & Synergies
Buying Guide
What to Look For
- • Purity
- • Third-party tested
- • MitoPrime branded
Standardization Markers
L-ergothioneine content
Adulteration risk
Low
Practical Notes
- • Body has dedicated transporter suggesting importance
- • Levels decline with age
- • Mushrooms are food source
Tags
amino-acidantioxidantlongevitymitochondria
More in Antioxidant
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C60 (Carbon 60 Fullerene)
Spherical carbon molecule with potent antioxidant properties in olive oil. Controversial with limited human data despite promising rodent longevity studies.
Citrus Bioflavonoids
Plant compounds from citrus fruits that enhance vitamin C absorption and provide antioxidant, anti-inflammatory, and vascular support benefits.
CoQ10 (Ubiquinone/Ubiquinol)
Ubiquinol is the reduced, active form of CoQ10 that plays a critical role in cellular energy production via the mitochondrial electron transport chain and serves as a lipid-soluble antioxidant. It is more bioavailable than standard ubiquinone (oxidized CoQ10), particularly in aging populations.
Last reviewed: June 2026 by the Formulate Research Team. Sources cited above; methodology and scoring criteria published here.
Cite this page
Formulate Research Team. (2026, June). Ergothioneine — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/ergothioneine
Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.