Essential mineral involved in 300+ enzymatic reactions. Supports energy, muscle function, sleep, and stress response.
Different chemical forms vary in absorption, side effects, and best use cases. Higher bioavailability scores indicate better absorption.
Magnesium bound to the amino acid glycine
💡 High bioavailability, gentle on stomach. Glycine itself has calming properties.
📝 Best all-around choice for most people
Chelated magnesium with two glycine molecules (same as glycinate)
💡 High bioavailability, identical to glycinate
📝 Marketing term often used interchangeably with glycinate
Magnesium bound to threonic acid, derived from vitamin C metabolism
💡 Uniquely crosses blood-brain barrier. Raises brain magnesium levels.
📝 Best choice for cognitive/brain health focus (Magtein brand)
Magnesium bound to the amino acid taurine
💡 Good bioavailability. Taurine adds cardiovascular benefits.
📝 Excellent choice for cardiovascular focus
Magnesium bound to malic acid
💡 Good bioavailability. Malic acid supports ATP production.
📝 Best for daytime energy and muscle support
Magnesium bound to citric acid
💡 Good bioavailability at normal doses
📝 Good budget option, may help with constipation
Magnesium bound to orotic acid
💡 Good bioavailability. Orotic acid may support heart tissue.
📝 Popular in Europe for cardiovascular support
Magnesium salt with chloride
💡 Moderate oral bioavailability. Often used topically.
📝 Best for topical magnesium oil/spray
Epsom salt - magnesium with sulfate
💡 Poor oral absorption. Strong laxative effect.
📝 Best for Epsom salt baths, not oral supplementation
Magnesium bound to oxygen - highest elemental magnesium but poorest absorption
💡 Only ~4% absorbed. Most passes through as laxative.
📝 Avoid for supplementation - only ~4% absorbed
Magnesium salt with carbonate
💡 Poor bioavailability, requires stomach acid
📝 Common in cheap supplements, not recommended
Milk of Magnesia
💡 Poor absorption. Primarily a laxative/antacid.
📝 Medical use only (Milk of Magnesia)
Long-term safe
Most adults deficient
Landmark clinical studies on Magnesium. Each title links to a plain-English breakdown — what the study shows, what its limitations are, and how to read around them.
8-week RCT in elderly with insomnia: 500mg/day magnesium significantly improved subjective insomnia score, sleep efficiency, sleep onset latency, and serum melatonin concentration.
Meta-analysis of 34 trials (n=2,028) found magnesium supplementation at a median dose of 368mg/day for 3 months significantly reduced systolic BP by 2.00 mmHg and diastolic BP by 1.78 mmHg.
Reviews mechanisms and clinical evidence for magnesium's role in migraine prophylaxis, stress, anxiety, and depression — with strongest RCT support for migraine prevention at 400–600mg/day.
Essential mineral with extensive research
Safe and important
Caution in kidney disease
Highest-scored catalog products containing Magnesium, ranked by our scoring engine.
In-depth guides covering Magnesium — protocols, comparisons, and use cases.
Other ingredients in the Mineral category.
Formulate Research Team. (2026, September). Magnesium — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/magnesium
Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.