Saccharomyces boulardii

Probiotic

Also known as: CNCM I-745, Florastor, S. boulardii

Grade A

💊 250-500 mg (5-10 billion cells) daily🎯 4 primary uses🔗 2 synergies⚠️ Review warnings

Overview

Beneficial yeast probiotic that's antibiotic-resistant. Excellent for diarrhea, C. diff, and antibiotic support.

Primary Uses

DiarrheaAntibiotic supportC. diff preventionTraveler's diarrhea

Dosage

Typical range

250-500 mg (5-10 billion cells) daily

Timing

During and after antibiotics

With food

Either way

Duration

During infection/antibiotics and 2 weeks after

Special Populations

Antibiotic users, recurrent C. diff

Mechanism of Action

• Not killed by antibiotics
• Secretes anti-toxin factors
• Supports gut barrier

Evidence Quality

Evidence Grade A

Strong evidence for diarrhea prevention

Safety & Contraindications

Serious Warnings

• Fungemia in immunocompromised with central lines

Contraindications

• Central venous catheter
• Severe immunocompromise

Common Side Effects

• Gas
• Bloating

Pregnancy & Breastfeeding

Consult healthcare provider

Liver & Kidney Notes

Safe

Interactions

💊 Medications

• Safe with antibiotics

🧪 Supplements

• Works with bacterial probiotics

🍽️ Food & Alcohol

• No interactions

Stacking & Synergies

Pairs Well With

LGGBacterial probiotics

Avoid Combining With

Antifungals reduce efficacy

Best Goal Synergies

Antibiotic supportDiarrhea

Buying Guide

What to Look For

• S. boulardii specifically

Standardization Markers

CFU or mg

Adulteration risk

Low

Practical Notes

• Safe during antibiotics
• Yeast - not killed by antibiotics

Frequently Asked About Saccharomyces boulardii

How much Saccharomyces boulardii should I take?

The typical effective range is 250-500 mg (5-10 billion cells) daily. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.

When is the best time to take Saccharomyces boulardii?

During and after antibiotics. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.

Should I take Saccharomyces boulardii with food?

Either way.

Does Saccharomyces boulardii interact with medications?

Yes — known interactions include Safe with antibiotics. If you take any prescription medication, talk to your doctor or pharmacist before starting Saccharomyces boulardii.

What does Saccharomyces boulardii pair well with?

Saccharomyces boulardii stacks well with LGG and Bacterial probiotics — these combinations either improve absorption or work synergistically toward common goals.

Who should not take Saccharomyces boulardii?

Saccharomyces boulardii should be avoided or used with caution by people with Central venous catheter and Severe immunocompromise. Pregnant or breastfeeding women should consult a healthcare provider before use.

What are the side effects of Saccharomyces boulardii?

Most people tolerate Saccharomyces boulardii well. The most commonly reported side effects are Gas and Bloating. Side effects are usually dose-dependent — lowering the dose often resolves them.

Related Guides

In-depth guides covering Saccharomyces boulardii — protocols, comparisons, and use cases.

Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.