Saccharomyces boulardii
Probiotic
Also known as: CNCM I-745, Florastor, S. boulardii
A
Grade A💊 250-500 mg (5-10 billion cells) daily🎯 4 primary uses🔗 2 synergies⚠️ Review warnings
Levels upNutrition+50 pts
Overview
Beneficial yeast probiotic that's antibiotic-resistant. Excellent for diarrhea, C. diff, and antibiotic support.
Primary Uses
DiarrheaAntibiotic supportC. diff preventionTraveler's diarrhea
Frequently Asked About Saccharomyces boulardii
How much Saccharomyces boulardii should I take?
The typical effective range is 250-500 mg (5-10 billion cells) daily. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take Saccharomyces boulardii?
During and after antibiotics. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take Saccharomyces boulardii with food?
Either way.
Does Saccharomyces boulardii interact with medications?
Yes — known interactions include Safe with antibiotics. If you take any prescription medication, talk to your doctor or pharmacist before starting Saccharomyces boulardii.
What does Saccharomyces boulardii pair well with?
Saccharomyces boulardii stacks well with LGG and Bacterial probiotics — these combinations either improve absorption or work synergistically toward common goals.
Who should not take Saccharomyces boulardii?
Saccharomyces boulardii should be avoided or used with caution by people with Central venous catheter and Severe immunocompromise. Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of Saccharomyces boulardii?
Most people tolerate Saccharomyces boulardii well. The most commonly reported side effects are Gas and Bloating. Side effects are usually dose-dependent — lowering the dose often resolves them.
Dosage
Typical range
250-500 mg (5-10 billion cells) daily
Timing
During and after antibiotics
With food
Either way
Duration
During infection/antibiotics and 2 weeks after
Special Populations
Antibiotic users, recurrent C. diff
Research & Studies
Search the literature now
We haven’t curated landmark studies for Saccharomyces boulardiiyet — one-click into the primary literature here. PubMed (RCTs) is usually the highest-signal starting point.
Search Saccharomyces boulardii research
Mechanism of Action
- • Not killed by antibiotics
- • Secretes anti-toxin factors
- • Supports gut barrier
Evidence Quality
Evidence Grade A
Strong evidence for diarrhea prevention
Safety & Contraindications
Serious Warnings
- • Fungemia in immunocompromised with central lines
Contraindications
- • Central venous catheter
- • Severe immunocompromise
Common Side Effects
- • Gas
- • Bloating
Pregnancy & Breastfeeding
Consult healthcare provider
Liver & Kidney Notes
Safe
Interactions
💊 Medications
- • Safe with antibiotics
🧪 Supplements
- • Works with bacterial probiotics
🍽️ Food & Alcohol
- • No interactions
Stacking & Synergies
Pairs Well With
LGG ↗Bacterial probiotics
Avoid Combining With
Antifungals reduce efficacy
Best Goal Synergies
Antibiotic supportDiarrhea
Buying Guide
What to Look For
- • S. boulardii specifically
Standardization Markers
CFU or mg
Adulteration risk
Low
Practical Notes
- • Safe during antibiotics
- • Yeast - not killed by antibiotics
Tags
probioticyeastdiarrheaantibiotic-resistant
Top Products with Saccharomyces boulardii
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Related Guides
In-depth guides covering Saccharomyces boulardii — protocols, comparisons, and use cases.
More in Probiotic
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Bifidobacterium infantis 35624
Most-studied probiotic strain for IBS. Repeated RCTs show symptom improvement at 1 billion CFU/day.
Bifidobacterium lactis
Hardy probiotic strain with strong immune-enhancing effects. Survives transit well and supports regularity.
Bifidobacterium longum
Dominant infant gut bacteria that supports immune function and may reduce anxiety. Important throughout life.
Lacticaseibacillus casei
A well-researched probiotic strain supporting digestive health, immune function, and overall gut microbiome balance.
Lactobacillus acidophilus
Foundational probiotic strain for vaginal and gut health. One of the most studied probiotic species.
Last reviewed: June 2026 by the Formulate Research Team. Sources cited above; methodology and scoring criteria published here.
Cite this page
Formulate Research Team. (2026, June). Saccharomyces boulardii — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/saccharomyces-boulardii
Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.