Vitamin B1 (Thiamine)

Also known as: Thiamine, Thiamin, Aneurin, Vitamin B1, vitamin-b1

Grade A

💊 25-100 mg daily🎯 7 primary uses🔗 2 synergies⚠️ Review warnings

Overview

Thiamine is an essential B-vitamin that functions as a coenzyme in carbohydrate and amino acid metabolism. Thiamine HCl is a stable, highly bioavailable form.

Primary Uses

Energy metabolismNerve functionCarbohydrate metabolismEnergy metabolism (carbohydrate and branched-chain amino acid oxidation)Nervous system function and myelin formationCognitive functionDeficiency prevention (Wernicke-Korsakoff syndrome)

Frequently Asked About Vitamin B1 (Thiamine)

How much Vitamin B1 (Thiamine) should I take?

The typical effective range is 50-100 mg. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.

When is the best time to take Vitamin B1 (Thiamine)?

With food. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.

Should I take Vitamin B1 (Thiamine) with food?

Yes.

What is the best form of Vitamin B1 (Thiamine)?

Benfotiamine is generally the best-absorbed form (Fat-soluble synthetic thiamine derivative). Cheaper forms exist but often deliver less usable Vitamin B1 (Thiamine) per dose.

Does Vitamin B1 (Thiamine) interact with medications?

Yes — known interactions include Loop diuretics deplete. If you take any prescription medication, talk to your doctor or pharmacist before starting Vitamin B1 (Thiamine).

What does Vitamin B1 (Thiamine) pair well with?

Vitamin B1 (Thiamine) stacks well with B-complex and Magnesium — these combinations either improve absorption or work synergistically toward common goals.

Who should not take Vitamin B1 (Thiamine)?

Vitamin B1 (Thiamine) should be avoided or used with caution by people with None. Pregnant or breastfeeding women should consult a healthcare provider before use.

Compare Forms

4 forms

Different chemical forms vary in absorption, side effects, and best use cases. Higher bioavailability scores indicate better absorption.

Benfotiamine

HIGH 100

Fat-soluble synthetic thiamine derivative

Best for:Diabetic neuropathyNerve healthBlood sugar support

💡 Excellent. 5x more bioavailable than thiamine HCl.

✅ Pros

• Much better absorption
• Fat-soluble
• Nerve protective
• Blood sugar support

⚠️ Cons

• Synthetic
• More expensive

📝 Best for therapeutic use, especially diabetic neuropathy

Sulbutiamine

HIGH 95

Synthetic thiamine that crosses blood-brain barrier

Best for:Cognitive enhancementFatigueMood support

💡 Excellent. Crosses blood-brain barrier.

✅ Pros

• Crosses BBB
• Cognitive benefits
• Mood/energy

⚠️ Cons

• Synthetic
• May cause tolerance

📝 Nootropic use - best for brain/mood

Thiamine HCl

GOOD 75

Standard water-soluble thiamine

Best for:Basic supplementationBudget option

💡 Moderate. Limited by transport mechanisms.

✅ Pros

• Inexpensive
• Widely available
• Safe

⚠️ Cons

• Limited absorption at higher doses

📝 Common but benfotiamine better absorbed

Thiamine Mononitrate

GOOD 75

Stable form used in food fortification

Best for:Food fortificationBasic supplementation

💡 Moderate

✅ Pros

• Very stable
• Inexpensive

⚠️ Cons

• Limited absorption

📝 Same bioavailability as thiamine HCl

Dosage

Typical range

25-100 mg daily

Timing

With food

Yes

Dose Tiers

RDA / DV

1.1-1.2 mg

Moderate

10-50 mg

Optimal

50-100 mg

Therapeutic

300-1,800 mg benfotiamine

Upper Limit

No established UL

Duration

Safe long-term

Special Populations

Alcoholics at high risk of deficiency

Research & Studies

Search the literature now

We haven’t curated landmark studies for Vitamin B1 (Thiamine)yet — one-click into the primary literature here. PubMed (RCTs) is usually the highest-signal starting point.

Search Vitamin B1 (Thiamine) research

PubMed (RCTs) ↗Randomized trials PubMed (all) ↗Full literature Cochrane Reviews ↗Systematic reviews Examine.com ↗Research summaries

Browse all curated studies →

Mechanism of Action

• Cofactor for pyruvate dehydrogenase
• Essential for acetyl-CoA production
• Supports nerve membrane function

Evidence Quality

Evidence Grade A

Essential B vitamin

Safety & Contraindications

Serious Warnings

• None at normal doses

Contraindications

• None

Common Side Effects

• Very safe

Pregnancy & Breastfeeding

Likely safe at normal doses - consult provider

Liver & Kidney Notes

Water-soluble, excreted

Interactions

💊 Medications

• Loop diuretics deplete

🧪 Supplements

• Works with B-complex

🍽️ Food & Alcohol

• Alcohol depletes thiamine

Stacking & Synergies

Pairs Well With

B-complex ↗Magnesium ↗

Avoid Combining With

None

Best Goal Synergies

EnergyNerve health

Buying Guide

What to Look For

• Benfotiamine for neuropathy

Standardization Markers

mg content

Adulteration risk

Low

Practical Notes

• Benfotiamine better for diabetic neuropathy
• Alcohol rapidly depletes

Top Products with Vitamin B1 (Thiamine)

Highest-scored catalog products containing Vitamin B1 (Thiamine), ranked by our scoring engine.

Browse all Vitamin B1 (Thiamine) products →

More in Vitamin

Other ingredients in the Vitamin category.

B-Complex (Energy Focus)

Essential coenzymes for energy metabolism. Methylated forms for optimal function.

Benfotiamine

Fat-soluble thiamine derivative with superior bioavailability. Particularly effective for diabetic neuropathy and AGE reduction.

Beta-Carotene

Provitamin A carotenoid converted to retinol as needed. Cannot cause toxicity. Provides independent antioxidant benefits.

Folate

Essential B vitamin for DNA synthesis, cell division, and methylation. Critical during pregnancy.

Methylfolate

Active form of folate for those with MTHFR variants. Critical for methylation and mood.

Multivitamin (Athletic Formula)

Broad-spectrum insurance for micronutrient gaps. Athletes may need more than RDA.

Browse all Vitamin ingredients →

Last reviewed: June 2026 by the Formulate Research Team. Sources cited above; methodology and scoring criteria published here.

Cite this page

Formulate Research Team. (2026, June). Vitamin B1 (Thiamine) — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/vitamin-b1

Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.