Luteolin
Antioxidant
Also known as: Luteolin flavonoid
B
Grade B💊 100-400mg daily🎯 4 primary uses🔗 3 synergies⚠️ Review warnings
Levels upHeart & Longevity+50 pts
Overview
Flavonoid with potent anti-inflammatory and neuroprotective properties. Inhibits mast cells and supports brain health.
Primary Uses
NeuroprotectionAnti-inflammatoryMast cell stabilizationBrain fog
Frequently Asked About Luteolin
How much Luteolin should I take?
The typical effective range is 100-400mg daily. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take Luteolin?
With meals. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take Luteolin with food?
Yes.
Does Luteolin interact with medications?
Yes — known interactions include Theoretical CYP interactions. If you take any prescription medication, talk to your doctor or pharmacist before starting Luteolin.
What does Luteolin pair well with?
Luteolin stacks well with Quercetin, PEA, and Curcumin — these combinations either improve absorption or work synergistically toward common goals.
Who should not take Luteolin?
Luteolin should be avoided or used with caution by people with Pregnancy. Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of Luteolin?
Most people tolerate Luteolin well. The most commonly reported side effects are Well tolerated and Mild GI. Side effects are usually dose-dependent — lowering the dose often resolves them.
Dosage
Typical range
100-400mg daily
Timing
With meals
With food
Yes
Duration
Safe long-term
Special Populations
Brain fog, mast cell issues, neuroinflammation
Research & Studies
Search the literature now
We haven’t curated landmark studies for Luteolinyet — one-click into the primary literature here. PubMed (RCTs) is usually the highest-signal starting point.
Mechanism of Action
- • Inhibits mast cell activation
- • Crosses blood-brain barrier
- • NF-kB inhibition
- • Microglial modulation
Evidence Quality
Evidence Grade B
Research supports anti-inflammatory and neuroprotective effects
Safety & Contraindications
Serious Warnings
- • None significant
Contraindications
- • Pregnancy
Common Side Effects
- • Well tolerated
- • Mild GI
Pregnancy & Breastfeeding
Avoid concentrated forms
Liver & Kidney Notes
Safe
Interactions
💊 Medications
- • Theoretical CYP interactions
🧪 Supplements
- • Quercetin synergy
🍽️ Food & Alcohol
- • Celery, peppers, chamomile sources
Stacking & Synergies
Pairs Well With
Avoid Combining With
None significant
Best Goal Synergies
NeuroinflammationBrain fogMast cell support
Buying Guide
What to Look For
- • Purity
- • Liposomal for brain
Standardization Markers
Luteolin content
Adulteration risk
Low
Practical Notes
- • Useful for brain fog and neuroinflammation
- • Mast cell stabilizing
- • Liposomal form for brain delivery
Tags
polyphenolflavonoidneuroprotectiveanti-inflammatory
Top Products with Luteolin
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Last reviewed: September 2026 by the Formulate Research Team. Sources cited above; methodology and scoring criteria published here.
Cite this page
Formulate Research Team. (2026, September). Luteolin — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/luteolin
Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.