Passionflower

Sleep

Also known as: Maypop, Passiflora incarnata, Passionflower 10:1 Extract (Passiflora incarnata), Passion Flower, Purple Passionflower

Grade B

💊 250-500 mg extract or as tea🎯 6 primary uses🔗 3 synergies⚠️ Review warnings

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Levels upSleep+50 pts

Overview

Passionflower is a traditional herbal anxiolytic used to support relaxation and sleep quality. A 10:1 extract concentrate provides a potent dose; moderate clinical evidence supports mild anxiolytic and sedative effects.

Primary Uses

AnxietySleepRelaxationAnxiety and nervous tensionSleep supportRestlessness and irritability

Frequently Asked About Passionflower

How much Passionflower should I take?

The typical effective range is 250-500 mg extract or as tea. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.

When is the best time to take Passionflower?

Evening or as needed. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.

Should I take Passionflower with food?

Optional.

Does Passionflower interact with medications?

Yes — known interactions include CNS depressants additive and Blood thinners. If you take any prescription medication, talk to your doctor or pharmacist before starting Passionflower.

What does Passionflower pair well with?

Passionflower stacks well with Valerian, Lemon balm, and L-theanine — these combinations either improve absorption or work synergistically toward common goals.

Who should not take Passionflower?

Passionflower should be avoided or used with caution by people with None. Pregnant or breastfeeding women should consult a healthcare provider before use.

What are the side effects of Passionflower?

Most people tolerate Passionflower well. The most commonly reported side effects are Drowsiness and Dizziness. Side effects are usually dose-dependent — lowering the dose often resolves them.

Dosage

Typical range

250-500 mg extract or as tea

Timing

Evening or as needed

With food

Optional

Duration

Safe long-term

Special Populations

Mild anxiety, sleep

Research & Studies

Search the literature now

We haven’t curated landmark studies for Passionfloweryet — one-click into the primary literature here. PubMed (RCTs) is usually the highest-signal starting point.

Search Passionflower research

PubMed (RCTs) ↗Randomized trials PubMed (all) ↗Full literature Cochrane Reviews ↗Systematic reviews Examine.com ↗Research summaries

Browse all curated studies →

Mechanism of Action

• MAO inhibition
• GABA-A modulation
• Adenosine receptor activity

Evidence Quality

Evidence Grade B

Gentle, safe anxiolytic herb

Safety & Contraindications

Serious Warnings

• None

Contraindications

• None

Common Side Effects

• Drowsiness
• Dizziness

Pregnancy & Breastfeeding

Avoid in pregnancy

Liver & Kidney Notes

Safe

Interactions

💊 Medications

• CNS depressants additive
• Blood thinners

🧪 Supplements

• Works with valerian, lemon balm

🍽️ Food & Alcohol

• No interactions

Stacking & Synergies

Pairs Well With

Valerian ↗Lemon balm ↗L-theanine ↗

Avoid Combining With

None

Best Goal Synergies

Gentle anxiety/sleep

Buying Guide

What to Look For

• Quality extract

Standardization Markers

Flavonoid content

Adulteration risk

Low

Practical Notes

• Very safe and gentle
• Good for anxiety-related sleep issues

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CBD Oil

Non-psychoactive cannabis compound for anxiety, pain, and sleep. Legal status varies.

Chamomile

Chamomile is a traditional herbal remedy with mild sedative and anxiolytic properties, supported by moderate clinical evidence for sleep quality and relaxation. Multiple studies suggest benefits for anxiety and digestive comfort, though effects are generally modest.

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Inhibitory neurotransmitter supplement with debated BBB penetration. May work peripherally for relaxation.

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Last reviewed: September 2026 by the Formulate Research Team. Sources cited above; methodology and scoring criteria published here.

Cite this page

Formulate Research Team. (2026, September). Passionflower — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/passionflower

Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.