Interaction Checker

Check interactions

Add your supplements, foods, meals — and any medications you take — to see how they interact. Findings are grouped by severity: what to avoid, what needs care or timing, and what actually works better together.

Best-Rest Formula

Add more (1/12)

Add a medication you take (optional)

Caution

18 · Combine carefully — read the note

Caution

Vitamin B6Levodopa

Vitamin B6: Levodopa

Known interaction

Caution

Vitamin B6Some seizure meds

Vitamin B6: Some seizure meds

Known interaction

Caution

MelatoninBlood thinners

Melatonin: Blood thinners

Known interaction

Caution

MelatoninImmunosuppressants

Melatonin: Immunosuppressants

Known interaction

Caution

MelatoninDiabetes meds

Melatonin: Diabetes meds

Known interaction

Caution

MelatoninCNS depressants

Melatonin: CNS depressants

Known interaction

Caution

GABA (Supplemental)CNS depressants may be additive

GABA (Supplemental): CNS depressants may be additive

Known interaction

Caution

L-TheanineMay enhance BP meds

L-Theanine: May enhance BP meds

Known interaction

Caution

ValerianCNS depressants

Valerian: CNS depressants

Known interaction

Caution

ValerianAnesthesia - stop before surgery

Valerian: Anesthesia - stop before surgery

Known interaction

Caution

Lemon BalmSedatives

Lemon Balm: Sedatives

Known interaction

Caution

Lemon BalmThyroid medications

Lemon Balm: Thyroid medications

Known interaction

Caution

HopsCNS depressants (benzodiazepines, alcohol, opioids) — additive sedation

Hops: CNS depressants (benzodiazepines, alcohol, opioids) — additive sedation

Known interaction

Caution

HopsHormone therapies

Hops: Hormone therapies

Known interaction

Caution

PassionflowerCNS depressants additive

Passionflower: CNS depressants additive

Known interaction

Caution

PassionflowerBlood thinners

Passionflower: Blood thinners

Known interaction

Caution

ApigeninCNS depressants

Apigenin: CNS depressants

Known interaction

Caution

ApigeninBlood thinners mild

Apigenin: Blood thinners mild

Known interaction

Works well together

11 · Beneficial pairing

Works well together

MelatoninL-Theanine

Melatonin pairs well with L-Theanine.

Stacking note

Works well together

GABA (Supplemental)L-Theanine

GABA (Supplemental) pairs well with L-Theanine.

Stacking note

Works well together

ValerianHops

Valerian pairs well with Hops.

Stacking note

Works well together

ValerianPassionflower

Valerian pairs well with Passionflower.

Stacking note

Works well together

ValerianLemon Balm

Valerian pairs well with Lemon Balm.

Stacking note

Works well together

Lemon BalmL-Theanine

Lemon Balm pairs well with L-Theanine.

Stacking note

Works well together

Lemon BalmPassionflower

Lemon Balm pairs well with Passionflower.

Stacking note

Works well together

HopsLemon Balm

Hops pairs well with Lemon Balm.

Stacking note

Works well together

HopsPassionflower

Hops pairs well with Passionflower.

Stacking note

Works well together

PassionflowerL-Theanine

Passionflower pairs well with L-Theanine.

Stacking note

Works well together

ApigeninL-Theanine

Apigenin pairs well with L-Theanine.

Stacking note

Not medical advice. This tool surfaces well-established and known interactions from our reference data and curated rules. It is not exhaustive, can’t see your full health picture, and an absence of findings does not mean a combination is safe. Always consult a doctor or pharmacist about your supplements and medications.