Bone
Hydroxyapatite formation, osteoblast cofactors
Bone mineralization lays calcium and phosphate down as hydroxyapatite crystals onto a collagen scaffold — and getting the calcium to the right place is a regulated chain, not a passive deposit. Vitamin D drives calcium absorption from the gut; vitamin K activates osteocalcin, the protein that binds that calcium into bone rather than letting it calcify arteries; magnesium and manganese are cofactors for the bone-building enzymes. Calcium without its directing vitamins (D and K) is the classic mistake — it raises blood calcium without reliably strengthening bone.
How your supplements + diet feed this pathway right now — the cofactors driving it, where the gaps are, and your own lab readouts.
The load-bearing nutrients — if these are deficient, this pathway slows down. Click any to see daily targets, food sources, and supplements that supply it.
Nutrients that contribute to this pathway but aren’t the single load-bearing inputs.
Lab markers that report on how well this pathway is running. When one of these is out of range, this pathway is often where the upstream issue lives.
Save a lab session under My Journey → Biomarkers to see your own values for these.
Pathways that share a load-bearing cofactor with this one.