Detox
CYP450 phase I + glutathione/sulfation/glycine phase II
The liver clears drugs, hormones, and toxins in two phases. Phase I (the CYP450 enzymes, fueled by B2 and B3) chemically alters a compound — but often into a more reactive, temporarily more toxic intermediate. Phase II then conjugates it, attaching glutathione, sulfate, glycine, or a methyl group to make it water-soluble and safe to excrete. The two have to stay balanced: a fast Phase I with a slow Phase II floods the body with reactive intermediates. NAC (for glutathione), glycine, taurine, selenium, and choline are the load-bearing inputs that keep Phase II keeping up.
How your supplements + diet feed this pathway right now — the cofactors driving it, where the gaps are, and your own lab readouts.
The load-bearing nutrients — if these are deficient, this pathway slows down. Click any to see daily targets, food sources, and supplements that supply it.
Nutrients that contribute to this pathway but aren’t the single load-bearing inputs.
Lab markers that report on how well this pathway is running. When one of these is out of range, this pathway is often where the upstream issue lives.
Save a lab session under My Journey → Biomarkers to see your own values for these.
Pathways that share a load-bearing cofactor with this one.