Nicotinamide Riboside (NR)
Longevity
Also known as: NR, Niagen, TruNiagen
B
Grade B💊 250-500 mg daily🎯 4 primary uses🔗 3 synergies⚠️ Review warnings
Levels upHeart & Longevity+50 pts
Overview
NAD+ precursor supporting cellular energy and longevity. May enhance neuroplasticity and mitochondrial function.
Primary Uses
NAD+ supportLongevityCellular energyNeuroprotection
Frequently Asked About Nicotinamide Riboside (NR)
How much Nicotinamide Riboside (NR) should I take?
The typical effective range is 250-500 mg daily. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take Nicotinamide Riboside (NR)?
Morning. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take Nicotinamide Riboside (NR) with food?
Optional.
Does Nicotinamide Riboside (NR) interact with medications?
Yes — known interactions include None significant. If you take any prescription medication, talk to your doctor or pharmacist before starting Nicotinamide Riboside (NR).
What does Nicotinamide Riboside (NR) pair well with?
Nicotinamide Riboside (NR) stacks well with Pterostilbene, TMG, and Resveratrol — these combinations either improve absorption or work synergistically toward common goals.
Who should not take Nicotinamide Riboside (NR)?
Nicotinamide Riboside (NR) should be avoided or used with caution by people with None known. Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of Nicotinamide Riboside (NR)?
Most people tolerate Nicotinamide Riboside (NR) well. The most commonly reported side effects are Mild nausea and Flushing rare. Side effects are usually dose-dependent — lowering the dose often resolves them.
Dosage
Typical range
250-500 mg daily
Timing
Morning
With food
Optional
Duration
Long-term benefits
Special Populations
Aging, energy concerns
Research & Studies
Search the literature now
We haven’t curated landmark studies for Nicotinamide Riboside (NR)yet — one-click into the primary literature here. PubMed (RCTs) is usually the highest-signal starting point.
Search Nicotinamide Riboside (NR) research
Mechanism of Action
- • Converted to NAD+ efficiently
- • Supports sirtuin activity
- • Mitochondrial biogenesis
Evidence Quality
Evidence Grade B
NAD+ precursor with longevity interest
Safety & Contraindications
Serious Warnings
- • None established
Contraindications
- • None known
Common Side Effects
- • Mild nausea
- • Flushing rare
Pregnancy & Breastfeeding
Limited data
Liver & Kidney Notes
Safe
Interactions
💊 Medications
- • None significant
🧪 Supplements
- • Works with pterostilbene
🍽️ Food & Alcohol
- • No interactions
Stacking & Synergies
Pairs Well With
Avoid Combining With
None
Best Goal Synergies
LongevityEnergy
Buying Guide
What to Look For
- • Niagen or TruNiagen brand
Standardization Markers
NR contentNiagen brand
Adulteration risk
Low
Practical Notes
- • Competes with NMN for NAD+ support
- • Well-studied brand important
Tags
longevityNAD+energymitochondria
Top Products with Nicotinamide Riboside (NR)
Highest-scored catalog products containing Nicotinamide Riboside (NR), ranked by our scoring engine.
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More in Longevity
Other ingredients in the Longevity category.
AKG (Alpha-Ketoglutarate)
AKG is a metabolic intermediate in the citric acid cycle that may support muscle protein synthesis and ammonia detoxification. Evidence for performance and body composition benefits in humans remains preliminary and limited.
Cycloastragenol
Astragalus-derived compound that may activate telomerase. Expensive and experimental telomere-focused longevity supplement.
He Shou Wu (Fo-Ti)
Traditional Chinese longevity herb for hair, vitality, and jing essence. Contains stilbenes and anthraquinones. Requires proper preparation.
NMN (Nicotinamide Mononucleotide)
Direct NAD+ precursor popularized by longevity research. Supports cellular repair and energy.
NR (Nicotinamide Riboside)
Another NAD+ precursor with good human data. May have different tissue distribution than NMN.
NR (Nicotinamide Riboside)
NAD+ precursor with extensive human safety data. First NAD+ precursor with significant clinical trials. Patented as Niagen.
Last reviewed: September 2026 by the Formulate Research Team. Sources cited above; methodology and scoring criteria published here.
Cite this page
Formulate Research Team. (2026, September). Nicotinamide Riboside (NR) — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/niacinamide-riboside
Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.