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โ† Encyclopedia

AKG (Alpha-Ketoglutarate)

Longevity

Also known as: AKG, ฮฑ-ketoglutaric acid, Calcium alpha-ketoglutarate, Ca-AKG, Alpha-Ketoglutaric Acid

B
Grade B
๐Ÿ’Š 300-1000mg daily๐ŸŽฏ 8 primary uses๐Ÿ”— 3 synergiesโš ๏ธ Review warnings

Overview

AKG is a metabolic intermediate in the citric acid cycle that may support muscle protein synthesis and ammonia detoxification. Evidence for performance and body composition benefits in humans remains preliminary and limited.

Primary Uses
LongevityEnergy productionBone healthCellular metabolismmuscle protein synthesisammonia metabolismexercise performancerecovery support

Dosage

Typical range
300-1000mg daily
Timing
Morning or pre-workout
With food
Optional
Duration

Safe in studies

Special Populations

Longevity, bone health, energy

Mechanism of Action

  • โ€ข Krebs cycle intermediate
  • โ€ข Glutamate precursor
  • โ€ข May reduce biological age markers
  • โ€ข Bone supportive (Ca-AKG)

Evidence Quality

Evidence Grade B

Promising longevity research, particularly Ca-AKG

Safety & Contraindications

Serious Warnings
  • โ€ข None significant
Contraindications
  • โ€ข None established
Common Side Effects
  • โ€ข Well tolerated
  • โ€ข GI upset rare
Pregnancy & Breastfeeding

Avoid, insufficient data

Liver & Kidney Notes

Safe

Interactions

๐Ÿ’Š Medications
  • โ€ข None significant
๐Ÿงช Supplements
  • โ€ข Part of longevity stacks
๐Ÿฝ๏ธ Food & Alcohol
  • โ€ข Flexible

Stacking & Synergies

Pairs Well With
Other longevity compoundsNMNGlycine
Avoid Combining With
None
Best Goal Synergies
LongevityBiological age reduction

Buying Guide

What to Look For
  • โ€ข Calcium AKG for longevity
  • โ€ข Third-party tested
Standardization Markers
AKG contentCalcium content for Ca-AKG
Adulteration risk
Low
Practical Notes
  • โ€ข Ca-AKG showed lifespan extension in mice
  • โ€ข Rejuvant uses Ca-AKG
  • โ€ข May reduce biological age markers
Tags
longevitykrebs-cycleboneenergymuscle recoverymetabolismamino acid metabolismperformance supplement

Frequently Asked About AKG (Alpha-Ketoglutarate)

How much AKG (Alpha-Ketoglutarate) should I take?
The typical effective range is 300-1000mg daily. Individual needs vary based on age, body weight, diet, and goals โ€” start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take AKG (Alpha-Ketoglutarate)?
Morning or pre-workout. Consistency matters more than perfect timing โ€” pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take AKG (Alpha-Ketoglutarate) with food?
Optional.
Does AKG (Alpha-Ketoglutarate) interact with medications?
Yes โ€” known interactions include None significant. If you take any prescription medication, talk to your doctor or pharmacist before starting AKG (Alpha-Ketoglutarate).
What does AKG (Alpha-Ketoglutarate) pair well with?
AKG (Alpha-Ketoglutarate) stacks well with Other longevity compounds, NMN, and Glycine โ€” these combinations either improve absorption or work synergistically toward common goals.
Who should not take AKG (Alpha-Ketoglutarate)?
AKG (Alpha-Ketoglutarate) should be avoided or used with caution by people with None established. Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of AKG (Alpha-Ketoglutarate)?
Most people tolerate AKG (Alpha-Ketoglutarate) well. The most commonly reported side effects are Well tolerated and GI upset rare. Side effects are usually dose-dependent โ€” lowering the dose often resolves them.

Educational content based on published research and our scoring methodology. Not medical advice โ€” consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.