AKG (Alpha-Ketoglutarate)
Longevity
Also known as: AKG, α-ketoglutaric acid, Calcium alpha-ketoglutarate, Ca-AKG, Alpha-Ketoglutaric Acid
B
Grade B💊 300-1000mg daily🎯 8 primary uses🔗 3 synergies⚠️ Review warnings
Levels upVitality+50 pts
Overview
AKG is a metabolic intermediate in the citric acid cycle that may support muscle protein synthesis and ammonia detoxification. Evidence for performance and body composition benefits in humans remains preliminary and limited.
Primary Uses
LongevityEnergy productionBone healthCellular metabolismmuscle protein synthesisammonia metabolismexercise performancerecovery support
Frequently Asked About AKG (Alpha-Ketoglutarate)
How much AKG (Alpha-Ketoglutarate) should I take?
The typical effective range is 300-1000mg daily. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take AKG (Alpha-Ketoglutarate)?
Morning or pre-workout. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take AKG (Alpha-Ketoglutarate) with food?
Optional.
Does AKG (Alpha-Ketoglutarate) interact with medications?
Yes — known interactions include None significant. If you take any prescription medication, talk to your doctor or pharmacist before starting AKG (Alpha-Ketoglutarate).
What does AKG (Alpha-Ketoglutarate) pair well with?
AKG (Alpha-Ketoglutarate) stacks well with Other longevity compounds, NMN, and Glycine — these combinations either improve absorption or work synergistically toward common goals.
Who should not take AKG (Alpha-Ketoglutarate)?
AKG (Alpha-Ketoglutarate) should be avoided or used with caution by people with None established. Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of AKG (Alpha-Ketoglutarate)?
Most people tolerate AKG (Alpha-Ketoglutarate) well. The most commonly reported side effects are Well tolerated and GI upset rare. Side effects are usually dose-dependent — lowering the dose often resolves them.
Dosage
Typical range
300-1000mg daily
Timing
Morning or pre-workout
With food
Optional
Duration
Safe in studies
Special Populations
Longevity, bone health, energy
Research & Studies
Search the literature now
We haven’t curated landmark studies for AKG (Alpha-Ketoglutarate)yet — one-click into the primary literature here. PubMed (RCTs) is usually the highest-signal starting point.
Search AKG (Alpha-Ketoglutarate) research
Mechanism of Action
- • Krebs cycle intermediate
- • Glutamate precursor
- • May reduce biological age markers
- • Bone supportive (Ca-AKG)
Evidence Quality
Evidence Grade B
Promising longevity research, particularly Ca-AKG
Safety & Contraindications
Serious Warnings
- • None significant
Contraindications
- • None established
Common Side Effects
- • Well tolerated
- • GI upset rare
Pregnancy & Breastfeeding
Avoid, insufficient data
Liver & Kidney Notes
Safe
Interactions
💊 Medications
- • None significant
🧪 Supplements
- • Part of longevity stacks
🍽️ Food & Alcohol
- • Flexible
Stacking & Synergies
Buying Guide
What to Look For
- • Calcium AKG for longevity
- • Third-party tested
Standardization Markers
AKG contentCalcium content for Ca-AKG
Adulteration risk
Low
Practical Notes
- • Ca-AKG showed lifespan extension in mice
- • Rejuvant uses Ca-AKG
- • May reduce biological age markers
Tags
longevitykrebs-cycleboneenergymuscle recoverymetabolismamino acid metabolismperformance supplement
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NMN (Nicotinamide Mononucleotide)
Direct NAD+ precursor popularized by longevity research. Supports cellular repair and energy.
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Last reviewed: June 2026 by the Formulate Research Team. Sources cited above; methodology and scoring criteria published here.
Cite this page
Formulate Research Team. (2026, June). AKG (Alpha-Ketoglutarate) — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/alpha-ketoglutarate
Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.