Also known as: AKG, α-ketoglutaric acid, Calcium alpha-ketoglutarate, Ca-AKG, Alpha-Ketoglutaric Acid
AKG is a metabolic intermediate in the citric acid cycle that may support muscle protein synthesis and ammonia detoxification. Evidence for performance and body composition benefits in humans remains preliminary and limited.
Safe in studies
Longevity, bone health, energy
We haven’t curated landmark studies for AKG (Alpha-Ketoglutarate)yet — one-click into the primary literature here. PubMed (RCTs) is usually the highest-signal starting point.
Promising longevity research, particularly Ca-AKG
Avoid, insufficient data
Safe
Other ingredients in the Longevity category.
Formulate Research Team. (2026, September). AKG (Alpha-Ketoglutarate) — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/alpha-ketoglutarate
Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.