NR (Nicotinamide Riboside)
Longevity
Also known as: Nicotinamide riboside, Niagen, NR chloride
B
Grade B💊 250-500mg daily🎯 4 primary uses🔗 3 synergies⚠️ Review warnings
Levels upVitality+50 pts
Overview
NAD+ precursor with extensive human safety data. First NAD+ precursor with significant clinical trials. Patented as Niagen.
Primary Uses
NAD+ supportCellular energyLongevityHealthy aging
Frequently Asked About NR (Nicotinamide Riboside)
How much NR (Nicotinamide Riboside) should I take?
The typical effective range is 250-500mg daily. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take NR (Nicotinamide Riboside)?
Morning. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take NR (Nicotinamide Riboside) with food?
Can be taken with or without.
Does NR (Nicotinamide Riboside) interact with medications?
Yes — known interactions include None significant. If you take any prescription medication, talk to your doctor or pharmacist before starting NR (Nicotinamide Riboside).
What does NR (Nicotinamide Riboside) pair well with?
NR (Nicotinamide Riboside) stacks well with Pterostilbene, TMG, and Resveratrol — these combinations either improve absorption or work synergistically toward common goals.
Who should not take NR (Nicotinamide Riboside)?
NR (Nicotinamide Riboside) should be avoided or used with caution by people with None established. Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of NR (Nicotinamide Riboside)?
Most people tolerate NR (Nicotinamide Riboside) well. The most commonly reported side effects are Well tolerated, Nausea rare, and Flushing rare. Side effects are usually dose-dependent — lowering the dose often resolves them.
Dosage
Typical range
250-500mg daily
Timing
Morning
With food
Can be taken with or without
Duration
Established safety profile
Special Populations
Longevity, energy, healthy aging
Research & Studies
Search the literature now
We haven’t curated landmark studies for NR (Nicotinamide Riboside)yet — one-click into the primary literature here. PubMed (RCTs) is usually the highest-signal starting point.
Search NR (Nicotinamide Riboside) research
Mechanism of Action
- • Converted to NMN then NAD+
- • Supports sirtuin activity
- • Mitochondrial function
- • Cellular repair pathways
Evidence Quality
Evidence Grade B
Good human trial data, established safety profile
Safety & Contraindications
Serious Warnings
- • None significant in trials
Contraindications
- • None established
Common Side Effects
- • Well tolerated
- • Nausea rare
- • Flushing rare
Pregnancy & Breastfeeding
Avoid, insufficient data
Liver & Kidney Notes
Safe
Interactions
💊 Medications
- • None significant
🧪 Supplements
- • Works with pterostilbene (basis)
🍽️ Food & Alcohol
- • Flexible
Stacking & Synergies
Pairs Well With
Avoid Combining With
None
Best Goal Synergies
NAD+ supportHealthy aging
Buying Guide
What to Look For
- • Niagen trademark
- • Third-party tested
Standardization Markers
Niagen brandedNR chloride content
Adulteration risk
Low with branded
Practical Notes
- • More human trial data than NMN
- • Niagen is quality-assured brand
- • Tru Niagen, Elysium Basis use NR
Tags
nad+longevityenergyaging
Related Guides
In-depth guides covering NR (Nicotinamide Riboside) — protocols, comparisons, and use cases.
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Cycloastragenol
Astragalus-derived compound that may activate telomerase. Expensive and experimental telomere-focused longevity supplement.
He Shou Wu (Fo-Ti)
Traditional Chinese longevity herb for hair, vitality, and jing essence. Contains stilbenes and anthraquinones. Requires proper preparation.
Nicotinamide Riboside (NR)
NAD+ precursor supporting cellular energy and longevity. May enhance neuroplasticity and mitochondrial function.
NMN (Nicotinamide Mononucleotide)
Direct NAD+ precursor popularized by longevity research. Supports cellular repair and energy.
NR (Nicotinamide Riboside)
Another NAD+ precursor with good human data. May have different tissue distribution than NMN.
Last reviewed: June 2026 by the Formulate Research Team. Sources cited above; methodology and scoring criteria published here.
Cite this page
Formulate Research Team. (2026, June). NR (Nicotinamide Riboside) — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/nr-nicotinamide-riboside
Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.