NR (Nicotinamide Riboside)
Longevity
Also known as: Niagen, TRU NIAGEN
B
Grade B💊 300-500mg daily🎯 3 primary uses🔗 3 synergies⚠️ Review warnings
Levels upVitality+50 pts
Overview
Another NAD+ precursor with good human data. May have different tissue distribution than NMN.
Primary Uses
NAD+ supportCellular energyLongevity
Frequently Asked About NR (Nicotinamide Riboside)
How much NR (Nicotinamide Riboside) should I take?
The typical effective range is 300-500mg daily. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take NR (Nicotinamide Riboside)?
Morning. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take NR (Nicotinamide Riboside) with food?
Optional.
Does NR (Nicotinamide Riboside) interact with medications?
Yes — known interactions include None significant known. If you take any prescription medication, talk to your doctor or pharmacist before starting NR (Nicotinamide Riboside).
What does NR (Nicotinamide Riboside) pair well with?
NR (Nicotinamide Riboside) stacks well with Pterostilbene, TMG, and CoQ10 — these combinations either improve absorption or work synergistically toward common goals.
Who should not take NR (Nicotinamide Riboside)?
NR (Nicotinamide Riboside) should be avoided or used with caution by people with Cancer (theoretical). Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of NR (Nicotinamide Riboside)?
Most people tolerate NR (Nicotinamide Riboside) well. The most commonly reported side effects are Mild flushing (less than niacin) and GI upset. Side effects are usually dose-dependent — lowering the dose often resolves them.
Dosage
Typical range
300-500mg daily
Timing
Morning
With food
Optional
Duration
Ongoing
Special Populations
Anti-aging, energy
Research & Studies
Search the literature now
We haven’t curated landmark studies for NR (Nicotinamide Riboside)yet — one-click into the primary literature here. PubMed (RCTs) is usually the highest-signal starting point.
Search NR (Nicotinamide Riboside) research
Mechanism of Action
- • Raises NAD+ levels
- • Cellular energy support
- • May support healthy aging
Evidence Quality
Evidence Grade B
Well-studied NAD+ precursor
Safety & Contraindications
Serious Warnings
- • None known
Contraindications
- • Cancer (theoretical)
Common Side Effects
- • Mild flushing (less than niacin)
- • GI upset
Pregnancy & Breastfeeding
Avoid (insufficient data)
Liver & Kidney Notes
Safe
Interactions
💊 Medications
- • None significant known
🧪 Supplements
- • May work with pterostilbene
🍽️ Food & Alcohol
- • No interactions
Stacking & Synergies
Pairs Well With
Avoid Combining With
None known
Best Goal Synergies
NAD+ supportLongevity
Buying Guide
What to Look For
- • Niagen brand or tested generic
Standardization Markers
NR contentNiagen certification
Adulteration risk
Low (patented)
Practical Notes
- • More human studies than NMN
- • Patented Niagen well-studied
Tags
longevityNAD+energycellular
Related Guides
In-depth guides covering NR (Nicotinamide Riboside) — protocols, comparisons, and use cases.
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He Shou Wu (Fo-Ti)
Traditional Chinese longevity herb for hair, vitality, and jing essence. Contains stilbenes and anthraquinones. Requires proper preparation.
Nicotinamide Riboside (NR)
NAD+ precursor supporting cellular energy and longevity. May enhance neuroplasticity and mitochondrial function.
NMN (Nicotinamide Mononucleotide)
Direct NAD+ precursor popularized by longevity research. Supports cellular repair and energy.
NR (Nicotinamide Riboside)
NAD+ precursor with extensive human safety data. First NAD+ precursor with significant clinical trials. Patented as Niagen.
Last reviewed: June 2026 by the Formulate Research Team. Sources cited above; methodology and scoring criteria published here.
Cite this page
Formulate Research Team. (2026, June). NR (Nicotinamide Riboside) — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/nad-precursor-nr
Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.