Cycloastragenol
Longevity
Also known as: CAG, TA-65 active compound, Astragaloside IV metabolite
C
Grade C💊 5-25mg daily🎯 3 primary uses🔗 1 synergy⚠️ Review warnings
Levels upVitality+50 pts
Overview
Astragalus-derived compound that may activate telomerase. Expensive and experimental telomere-focused longevity supplement.
Primary Uses
Telomere supportLongevityImmune function
Frequently Asked About Cycloastragenol
How much Cycloastragenol should I take?
The typical effective range is 5-25mg daily. Individual needs vary based on age, body weight, diet, and goals — start at the lower end and adjust based on response. Always consult a healthcare provider before starting a new supplement.
When is the best time to take Cycloastragenol?
Any time. Consistency matters more than perfect timing — pick a daily anchor (e.g. with breakfast or before bed) and stick with it.
Should I take Cycloastragenol with food?
Optional.
Does Cycloastragenol interact with medications?
Yes — known interactions include Unknown. If you take any prescription medication, talk to your doctor or pharmacist before starting Cycloastragenol.
What does Cycloastragenol pair well with?
Cycloastragenol stacks well with Other longevity compounds — these combinations either improve absorption or work synergistically toward common goals.
Who should not take Cycloastragenol?
Cycloastragenol should be avoided or used with caution by people with History of cancer (theoretical). Pregnant or breastfeeding women should consult a healthcare provider before use.
What are the side effects of Cycloastragenol?
Most people tolerate Cycloastragenol well. The most commonly reported side effects are Limited data, appears tolerated. Side effects are usually dose-dependent — lowering the dose often resolves them.
Dosage
Typical range
5-25mg daily
Timing
Any time
With food
Optional
Duration
Long-term safety data limited
Special Populations
Telomere/longevity focused
Research & Studies
Search the literature now
We haven’t curated landmark studies for Cycloastragenolyet — one-click into the primary literature here. PubMed (RCTs) is usually the highest-signal starting point.
Mechanism of Action
- • May activate telomerase
- • Derived from astragalus
- • Immune-supporting properties
- • Expensive longevity compound
Evidence Quality
Evidence Grade C
Telomerase activation shown in vitro, human evidence limited
Safety & Contraindications
Serious Warnings
- • Theoretical cancer concern (telomerase activation)
- • Very expensive
Contraindications
- • History of cancer (theoretical)
Common Side Effects
- • Limited data, appears tolerated
Pregnancy & Breastfeeding
Avoid
Liver & Kidney Notes
Limited data
Interactions
💊 Medications
- • Unknown
🧪 Supplements
- • Part of longevity stacks
🍽️ Food & Alcohol
- • Astragalus root is source
Stacking & Synergies
Pairs Well With
Other longevity compounds
Avoid Combining With
None established
Best Goal Synergies
Telomere supportLongevity
Buying Guide
What to Look For
- • Third-party verified
- • Reputable source
Standardization Markers
Cycloastragenol content
Adulteration risk
Moderate
Practical Notes
- • Very expensive
- • Telomerase activation controversial
- • TA-65 is branded version
Tags
telomerelongevityastragalustelomerase
More in Longevity
Other ingredients in the Longevity category.
AKG (Alpha-Ketoglutarate)
AKG is a metabolic intermediate in the citric acid cycle that may support muscle protein synthesis and ammonia detoxification. Evidence for performance and body composition benefits in humans remains preliminary and limited.
He Shou Wu (Fo-Ti)
Traditional Chinese longevity herb for hair, vitality, and jing essence. Contains stilbenes and anthraquinones. Requires proper preparation.
Nicotinamide Riboside (NR)
NAD+ precursor supporting cellular energy and longevity. May enhance neuroplasticity and mitochondrial function.
NMN (Nicotinamide Mononucleotide)
Direct NAD+ precursor popularized by longevity research. Supports cellular repair and energy.
NR (Nicotinamide Riboside)
Another NAD+ precursor with good human data. May have different tissue distribution than NMN.
NR (Nicotinamide Riboside)
NAD+ precursor with extensive human safety data. First NAD+ precursor with significant clinical trials. Patented as Niagen.
Last reviewed: June 2026 by the Formulate Research Team. Sources cited above; methodology and scoring criteria published here.
Cite this page
Formulate Research Team. (2026, June). Cycloastragenol — Evidence-Based Supplement Guide. Formulate Supplement Encyclopedia. https://app.formulate-health.app/learning/supplements/cycloastragenol
Educational content based on published research and our scoring methodology. Not medical advice — consult a qualified healthcare provider before starting, stopping, or changing supplements, especially if you take medications, are pregnant, or have a medical condition.