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Body System

Stress

HPA-axis + adrenal cofactor support

The body's stress response runs through the HPA axis — hypothalamus → pituitary → adrenal glands → cortisol — and sustaining it burns through specific nutrients fast. Vitamin C and vitamin B5 (pantothenic acid) are concentrated in the adrenal glands and consumed in the making of cortisol; magnesium is depleted by stress, and its depletion in turn amplifies the stress response — a self-reinforcing loop. L-theanine, glycine, and taurine supply the calming, inhibitory side that lets the system stand back down. Chronic stress without these inputs leaves the axis dysregulated: wired-but-tired, poor sleep, blunted recovery.

See your coverage for the Stress system

How your supplements + diet cover this system right now — the nutrients feeding it, where the gaps are, and your own lab readouts.

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Primary nutrients

The load-bearing nutrients — if these are deficient, this system shows symptoms first. Click any to see daily targets, top food sources, and supplements that supply it.

Additional supporting nutrients
Biomarkers on this system

Lab markers that report on this system’s health.

🩸 Reverse T3🩸 DHEA-Sulfate🩸 Cortisol (AM)

Save a lab session under My Journey → Biomarkers to see your own values for these.

Pathways that power this system

Where the biochemistry happens for this system.

Related systems

Systems that share a load-bearing nutrient with this one.