Check interactions
Add your supplements, foods, meals — and any medications you take — to see how they interact. Findings are grouped by severity: what to avoid, what needs care or timing, and what actually works better together.
Add more (1/12)
Avoid
3 · Don't combine without medical guidanceVitamin K directly counteracts warfarin — it can restore clotting and raise clot risk.
Why: Vitamin K is the antidote to warfarin; it regenerates the clotting factors warfarin suppresses.
→ Do not start/stop vitamin K without your prescriber; keep intake consistent and monitor INR.
Reduces anticoagulant effect
Why: Same as warfarin - vitamin K antagonism
Reduces anticoagulant effect
Why: Vitamin K antagonist anticoagulant
Caution
41 · Combine carefully — read the noteHigh-dose vitamin E can increase bleeding risk with blood thinners.
Why: Mild antiplatelet effect at high doses.
→ Avoid high doses without prescriber guidance.
Antibiotics kill gut bacteria that produce vitamin K2; may need more K
Why: Reduced intestinal vitamin K synthesis
Can cause vitamin K deficiency; bleeding risk
Why: Interfere with vitamin K recycling
Reduces vitamin K absorption
Why: Binds fat-soluble vitamins in gut
Reduces vitamin K absorption
Why: Blocks fat absorption including fat-soluble vitamins
High vitamin E may interfere with vitamin K function
Why: Competitive inhibition of vitamin K-dependent clotting
Reduces vitamin K absorption
Why: Fat-soluble vitamin binding
Chromium Picolinate: May enhance diabetes meds
Copper: Penicillamine, zinc, antacids reduce absorption
Lycopene: May have additive antiplatelet effects with warfarin or antiplatelet drugs (rare, clinical significance unclear)
Vitamin B1 (Thiamine): Loop diuretics deplete
Vitamin B12 (Cobalamin): Metformin reduces absorption
Vitamin B12 (Cobalamin): PPIs reduce absorption
Vitamin B2 (Riboflavin): None significant
Niacin (Vitamin B3): Statins (myopathy risk)
Niacin (Vitamin B3): Blood pressure meds
Vitamin D: Glucocorticoids (reduced vitamin D effectiveness)
Vitamin D: Anticonvulsants like phenytoin (increased vitamin D metabolism)
Vitamin D: Orlistat (reduced fat-soluble vitamin absorption)
Vitamin K: Warfarin - must keep intake consistent
Selenium: May affect thyroid medication needs
Monitor / Timing
11 · Usually fine — mind timing or watch for effectsMagnesium can bind these drugs and reduce their absorption.
Why: Cation chelation in the gut.
→ Separate magnesium from these medications by 2–4 hours.
Calcium can bind these drugs and reduce their absorption.
Why: Cation chelation in the gut.
→ Separate calcium from these medications by 2–4 hours.
Minimal interaction - does not depend on vitamin K
Why: Direct factor Xa inhibitor - not vitamin K dependent
Minimal interaction
Why: Direct factor Xa inhibitor
Minimal interaction
Why: Direct thrombin inhibitor
May reduce vitamin K levels
Why: Gut bacteria disruption
May reduce vitamin K absorption
Why: Less effect than older agents
May interfere with vitamin K absorption
Why: Competition for absorption
Works well together
22 · Beneficial pairingVitamin B1 (Thiamine) pairs well with Magnesium.
Vitamin B12 (Cobalamin) pairs well with Folate.
Vitamin B2 (Riboflavin) pairs well with Magnesium.
