Add your supplements, foods, meals — and any medications you take — to see how they interact. Findings are grouped by severity: what to avoid, what needs care or timing, and what actually works better together.
5-HTP plus serotonergic drugs can cause serotonin syndrome (dangerous).
Why: Both raise serotonin; additive/excess serotonergic activity.
→ Do not combine without medical supervision.
High-dose vitamin E can increase bleeding risk with blood thinners.
Why: Mild antiplatelet effect at high doses.
→ Avoid high doses without prescriber guidance.
High-dose fish oil can add to a blood thinner's effect and increase bleeding risk.
Why: EPA/DHA reduce platelet aggregation.
→ Discuss high doses with your prescriber; watch for easy bruising/bleeding.
Vitamin D: Glucocorticoids (reduced vitamin D effectiveness)
Vitamin D: Anticonvulsants like phenytoin (increased vitamin D metabolism)
Vitamin D: Orlistat (reduced fat-soluble vitamin absorption)
Vitamin B1 (Thiamine): Loop diuretics deplete
Vitamin B2 (Riboflavin): None significant
Niacin (Vitamin B3): Statins (myopathy risk)
Niacin (Vitamin B3): Blood pressure meds
Vitamin B12 (Cobalamin): Metformin reduces absorption
Vitamin B12 (Cobalamin): PPIs reduce absorption
Choline (Various Forms): May interact with anticholinergics
Selenium: May affect thyroid medication needs
Chromium Picolinate: May enhance diabetes meds
Inositol: Lithium (may reduce inositol)
CoQ10 (Ubiquinone/Ubiquinol): Statins deplete - always supplement
CoQ10 (Ubiquinone/Ubiquinol): Blood thinners - may reduce effect
Alpha-Lipoic Acid (ALA): Diabetes meds - enhance effect
Lycopene: May have additive antiplatelet effects with warfarin or antiplatelet drugs (rare, clinical significance unclear)
5-HTP: SSRIs, MAOIs, triptans - serious interaction
Fish Oil (EPA/DHA): Blood thinners additive
Fish Oil (EPA/DHA): BP meds may enhance
Magnesium can bind these drugs and reduce their absorption.
Why: Cation chelation in the gut.
→ Separate magnesium from these medications by 2–4 hours.
Vitamin D: Magnesium (needed for vitamin D metabolism)
Vitamin E pairs well with CoQ10 (Ubiquinone/Ubiquinol).
Vitamin B1 (Thiamine) pairs well with Magnesium.
Vitamin B2 (Riboflavin) pairs well with Magnesium.
Vitamin B2 (Riboflavin) pairs well with CoQ10 (Ubiquinone/Ubiquinol).
Folate pairs well with Vitamin B12 (Cobalamin).
Chromium Picolinate pairs well with Alpha-Lipoic Acid (ALA).
CoQ10 (Ubiquinone/Ubiquinol) pairs well with Magnesium.
Taurine pairs well with CoQ10 (Ubiquinone/Ubiquinol).
Fish Oil (EPA/DHA) pairs well with Vitamin D.
Fish Oil (EPA/DHA) pairs well with Vitamin E.
